Results 41 to 50 of about 7,158 (300)

Development of Interactive Learning Media on Simple Flat Buildings Material "BADANA" for Students Grade III Elementary School

Inovasi Matematika, 2023
Tujuan penelitian ini yaitu guna menghasilkan produk dari rancangan media pembelajaran interaktif articulate storyline “BADANA”. Penelitian ini mendeskripsikan mengenai kelayakan media yang dihasilkan dari validasi dari ahli bahasa, media serta ahli ...
Novia Sari, Yeni Yuniarti
doaj   +1 more source

Visionary Leadership in Building Achievement Characters in Elementary Schools

Madrasah: Jurnal Pendidikan dan Pembelajaran Dasar, 2021
The purpose of this study is to describe the visionary leadership model in shaping the character of student achievement in SD Unggulan Al-Ya'lu Malang. This research uses descriptive qualitative. Retrieval of data using observation, interviews and documentation. Observations are used to support the leadership process announced by the vision in the form
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Building trust in elementary schools: the impact of home school community collaboration

International Journal about Parents in Education, 2023
There is a general consensus among contemporary social scientists that social trust is important(Alexander, 2003; Coleman, 1990; Delhey & Newton, 2003; Huang, 2003; Putnam, 1993). In thecontext of education, trust was seen as a goal and a tool for school improvement (Meier, 2002; Brown, 1998; Schneider & Bryk, 2002).
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Asesmen Cepat Kerentanan Bangunan Sekolah Muhammadiyah Terhadap Gempabumi di Kecamatan Kasihan Bantul DIY

Semesta Teknika, 2017
School buildings are included as buildings with risk category IV (SNI 1726: 2012) because it is potentially causing multiple casualties if earthquakes occur during school hours.
Restu Faizah, Muhammad Ibnu Syamsi
doaj  

Pemanfaatan Bangunan Cagar Budaya di Area Duizen Vierkanten Paal Kota Pontianak sebagai Sumber Pembelajaran Sejarah

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan, 2021
One of the historical relics is a cultural heritage building. Cultural heritage buildings located around student are necessary and important to be introduced to them so that they will be interested in studying history.
Haris Firmansyah
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source