Results 71 to 80 of about 12,772,364 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Entrepreneurial Soul in Primary School Students: Qualitative approach

Journal of Economics Education and Entrepreneurship
Introducing an entrepreneurial spirit to elementary school students is an important role very important in increasing their independence and has many benefits very good and will have an impact on his future.
Sundahry Sundahry, Fauziah Fauziah, Subhanadri Subhanadri, Firman Firman   +3 more
doaj   +1 more source

PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH SISWA SEKOLAH DASAR MENGGUNAKAN MODEL PROBLEM-BASED LEARNING

Primary: Jurnal Pendidikan Guru Sekolah Dasar, 2020
The background of this study is due to the low ability of problem-solving at elementary school students. The purpose of this study was to determine the improvement of the problem-solving abilities of elementary school students using problem-based ...
Faddylla Intan Maharani, Maria Montessori   +1 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

IMPACT OF ENGLISH INSTRUCTION AT THE ELEMENTARY SCHOOLS ON THE STUDENTS' ACHIEVEMENT OF ENGLISH AT THE LOWER SECONDARY SCHOOL

TEFLIN Journal, 2008
The current study is intended to examine the effect of time of learning, English teachers' characteristics, teaching and learning process characteristics, socioeconomic context and students' characteristics in the teaching of English at the elementary ...
Sri Rachmajanti
doaj   +3 more sources

The Effect of Experiential Learning Models Toward Writing Skills of Narration Primary School Student

International Journal of Science and Applied Science: Conference Series, 2019
Learning to write in elementary school is currently not getting serious attention. This results in the poor quality of students' narrative writing. This study aims to determine the effect of experiential learning models on the narrative writing skills of
Risma Nuriyanti, Rahman Rahman, Ernawulan Syaodih, Prana Dwija Iswara, Agus Muharam   +4 more
doaj   +1 more source

Hope and School Leadership for Elementary School Students

Journal of School Administration Research and Development
This study sought to identify how first-grade students in one Midwest state cognized hope. Using a case-study research method, the authors identify recommendations for practice that draw on the alignment between developing hope in students through school leadership.
Amber O'Shea, Cailen O’Shea
openaire   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source