Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test [PDF]
Molecular Brain, 2021 The elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables can influence elevated plus ...
Hirotaka Shoji, Tsuyoshi Miyakawa
doaj +3 more sources
Comparative analysis between Open Field and Elevated Plus Maze tests as a method for evaluating anxiety-like behavior in mice [PDF]
Heliyon, 2023 Anxiety is being increasingly diagnosed in the elderly population. In this sense, epidemiologic data have linked late-life anxiety disorders to increased cognitive decline, morbidity, and even mortality.
Mariah Mesquita de Figueiredo Cerqueira +6 more
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Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze. [PDF]
J Psychopharmacol, 2022 Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only acute effects of CBD and only in males, yet the drug is most likely to be ...
Fabris D +8 more
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Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze. [PDF]
Eur J Neurosci, 2023 Fear and anxiety are adaptive states that allow humans and animals alike to respond appropriately to threatening cues in their environment. Commonly used tasks for studying behaviour akin to fear and anxiety in rodent models are Pavlovian threat ...
Hilton JR +9 more
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Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats. [PDF]
Behav Pharmacol, 2022 The prescription opioid oxycodone is widely used for the treatment of pain in humans. Oxycodone misuse is more common among people with an anxiety disorder than those without one. Therefore, oxycodone might be misused for its anxiolytic properties.
Bruijnzeel AW +7 more
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High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test. [PDF]
Nutrients, 2020 Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models.
Yoshizaki K, Asai M, Hara T.
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Time-of-Day and Age Impact on Memory in Elevated Plus-Maze Test in Rats. [PDF]
Front Behav Neurosci, 2018 The purpose of the present study was to establish the effect of daytime and aging on memory in rats in the Elevated Plus-Maze (EPM) test. Young (2-months) and aged (18-months) male Wistar rats were exposed to the EPM test, at the beginning, mid-time or ...
Morales-Delgado N +4 more
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An elevated plus-maze in mixed reality for studying human anxiety-related behavior. [PDF]
BMC Biol, 2017 BackgroundA dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents.MethodsHere, we
Biedermann SV +10 more
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Repeated elevated plus maze trials as a measure for tracking within-subjects behavioral performance in rats (Rattus norvegicus). [PDF]
PLoS One, 2018 The elevated plus maze (EPM) is routinely used in neuroscience research to evaluate emotional behavior in rodents by measuring general exploratory performance and avoidance of the aversive open arms of the maze.
Schrader AJ +3 more
europepmc +2 more sources
Characterization of Peripheral Activity States and Cortical Local Field Potentials of Mice in an Elevated Plus Maze Test. [PDF]
Front Behav Neurosci, 2018 Elevated plus maze (EPM) tests have been used to assess animal anxiety levels. Little information is known regarding how physiological activity patterns of the brain-body system are altered during EPM tests.
Okonogi T +3 more
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