Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test [PDF]
Molecular Brain, 2021 The elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables can influence elevated plus ...
Hirotaka Shoji, Tsuyoshi Miyakawa
doaj +3 more sources
Time-of-Day and Age Impact on Memory in Elevated Plus-Maze Test in Rats [PDF]
Frontiers in Behavioral Neuroscience, 2018 The purpose of the present study was to establish the effect of daytime and aging on memory in rats in the Elevated Plus-Maze (EPM) test. Young (2-months) and aged (18-months) male Wistar rats were exposed to the EPM test, at the beginning, mid-time or ...
Nicanor Morales-Delgado +8 more
doaj +3 more sources
Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze. [PDF]
J Psychopharmacol, 2022 Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only acute effects of CBD and only in males, yet the drug is most likely to be ...
Fabris D +8 more
europepmc +2 more sources
Comparative analysis between Open Field and Elevated Plus Maze tests as a method for evaluating anxiety-like behavior in mice. [PDF]
Heliyon, 2023 Anxiety is being increasingly diagnosed in the elderly population. In this sense, epidemiologic data have linked late-life anxiety disorders to increased cognitive decline, morbidity, and even mortality.
Figueiredo Cerqueira MM +6 more
europepmc +2 more sources
Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats. [PDF]
Pharmacol Biochem Behav, 2021 There is a growing need for a better understanding of sex differences in animal models of psychiatric disorders. The elevated plus-maze (EPM) test and large open field (LOF) test are widely used to study anxiety-like behavior in rodents.
Knight P +5 more
europepmc +2 more sources
High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test. [PDF]
Nutrients, 2020 Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models.
Yoshizaki K, Asai M, Hara T.
europepmc +2 more sources
Restraint-induced hypoactivity in an elevated plus-maze [PDF]
Brazilian Journal of Medical and Biological Research, 2000 Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes.
C.M. Padovan, F.S. Guimarães
doaj +4 more sources
An elevated plus-maze in mixed reality for studying human anxiety-related behavior. [PDF]
BMC Biol, 2017 BackgroundA dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents.MethodsHere, we
Biedermann SV +10 more
europepmc +2 more sources
Repeated elevated plus maze trials as a measure for tracking within-subjects behavioral performance in rats (Rattus norvegicus). [PDF]
PLoS One, 2018 The elevated plus maze (EPM) is routinely used in neuroscience research to evaluate emotional behavior in rodents by measuring general exploratory performance and avoidance of the aversive open arms of the maze.
Schrader AJ +3 more
europepmc +2 more sources
Effect of apparatus characteristics on anxiety-like behavior in young adult and old mice of both sexes assessed by the elevated plus maze assay [PDF]
Frontiers in Behavioral Neuroscience, 2023 Incidence of anxiety-like disorders in humans has been shown to decrease with aging; however, it is still under debate whether there are similarities in mice, which would support the use of mouse models in understanding the neuronal network changes that ...
Lauren Gaspar +7 more
doaj +2 more sources