Results 161 to 170 of about 106,332 (235)
Some of the next articles are maybe not open access.
Anxiety, defence and the elevated plus-maze.
Neuroscience & Biobehavioral Reviews, 1997The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and is representative of those tests that are based upon the study of spontaneous behaviour patterns and which have high ecological validity. The origins of the test in studies of the relationship between exploration and fear are reviewed, and attention is drawn to ...
R. Rodgers, A. Dalvi
semanticscholar +3 more sources
Anxiogenic stimuli in the elevated plus-maze.
Pharmacology Biochemistry and Behavior, 1993Untreated rats normally avoid the open arms of the "elevated plus-maze," preferring instead the closed arms, whereas rats treated with antianxiety drugs (e.g., diazepam) show far less open-arm avoidance. Although it has often been assumed that rats avoid the open arms because of novelty, height, or open space, the anxiogenic role of these stimuli in ...
D. Treit, Janet L. Menard, Cary Royan
semanticscholar +3 more sources
Ethopharmacological analysis of rat behavior on the elevated plus-maze.
Pharmacology Biochemistry and Behavior, 1994Behavioral categories were measured in rats left on an elevated plus-maze for 5 min, in addition to the traditional measures. Four independent factors emerged from a factor analysis. The variables that loaded highly and positively on Factor 1, seemingly related with anxiety, were: number of entries onto open arms, time spent on open arms, percentage of
A. Cruz +3 more
semanticscholar +4 more sources
Elevated Plus Maze for Assessment of Anxiety and Memory in Rodents.
Methods in molecular biologyThe elevated plus maze is the most widely used paradigm to evaluate anxiety-associated behavioral alterations in rodent models of central nervous system (CNS) disorders. Unconditioned aversive behavior for open and elevated areas is a measure of anxiety and can be assessed by the plus maze.
R. C. S. R. Danduga, P. K. Kola
semanticscholar +3 more sources
Temporal structure of the rat's behavior in elevated plus maze test.
Behavioural Brain Research, 2013Aim of the research was to evaluate, by means of quantitative and multivariate temporal pattern analyses, the behavior of Wistar rat in elevated plus maze (EPM) test. On the basis of an ethogram encompassing 24 behavioral elements, quantitative results showed that 130.14 ± 8.01 behavioral elements occurred in central platform and in closed arms ...
M. Casarrubea +6 more
semanticscholar +6 more sources
Ethopharmacological analysis of the open elevated plus-maze in mice.
Behavioural Brain Research, 2013Exposure of rodents to an open elevated plus-maze (oEPM) elicits antinociception and increases plasma corticosterone levels. However, no studies have yet assessed the defensive behaviour repertoire of animals in this modified test. In Experiment 1, factor analysis was employed to characterise the behavioural profile of mice exposed to the oEPM ...
T. Sorregotti +4 more
semanticscholar +4 more sources
The Elevated Plus Maze Test for Measuring Anxiety-Like Behavior in Rodents.
Methods in molecular biology, 2018The elevated plus maze test is used to measure anxiety-like behavior in rodents. It can be used to gain insight into conditions such as posttraumatic stress disorder (PTSD) and other conditions marked by anxious behavior. It can also be used as a component in screening of novel compounds for anxiolytic properties.
A. Kraeuter, P. Guest, Z. Sarnyai
semanticscholar +4 more sources