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Mathematical methods to model rodent behavior in the elevated plus-maze.
Journal of Neuroscience Methods, 2013The elevated plus maze is a widely used experimental test to study anxiety-like rodent behavior. It is made of four arms, two open and two closed, connected at a central area forming a plus shaped maze. The whole apparatus is elevated 50 cm from the floor.
R. Arantes +4 more
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Elevated Plus Maze on Based Computer Vision
2007 IEEE 15th Signal Processing and Communications Applications, 2007This paper presents a novel method for rat detection and tracking in a platform known as elevated-plus maze and for recording the rat movements as a time elapsed in specific regions in real time surveillance systems. First, the location of plus maze platform is automatically determined by using hough transform.
Mustafa Sahin +3 more
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Antianxiety effect of cannabidiol in the elevated plus-maze
Psychopharmacology, 1990In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective.
F S, Guimarães +3 more
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Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze
General Pharmacology: The Vascular System, 19941. In order to assess the presence of anxiolytic properties in cannabidiol (CBD) derivatives HU-219, HU-252 and HU-261, these drugs were tested in rats submitted to the elevated plus-maze model of anxiety. 2. Additional groups received diazepam or CBD.
F S, Guimarães +3 more
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Behavior ontogeny in the elevated plus‐maze: prenatal stress effects
International Journal of Developmental Neuroscience, 2006AbstractPrenatal stress is a putative model for studying some psychopathological disorders. Indeed, submitting pregnant animals to stress leads to enhanced anxiety in the adult offspring. However, little is known about how prenatal stress effects interacts with anxiety throughout development. To study this issue, prenatally stressed rats were tested in
Celio, Estanislau, Silvio, Morato
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Pharmacological characterization of cannabinoids in the elevated plus maze.
The Journal of Pharmacology and Experimental Therapeutics, 1990delta 9-Tetrahydrocannabinol (delta 9-THC) induced in both rats and mice an increased aversion to the open arms of the elevated plus maze which was similar to that produced by anxiogenic agents. This effect of delta 9-THC was approximately three times greater in rats than in mice.
E S, Onaivi, M R, Green, B R, Martin
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MK-801 induced amnesia for the elevated plus-maze in mice
Behavioural Brain Research, 2002MK-801, a non-competitive NMDA receptor antagonist, has been shown to have amnesic properties in animal models. The purpose of the present study was to examine potential amnesic effects of MK-801 in mice using the modified elevated plus-maze paradigm. An animal was placed on the distal end of an open arm, and the transfer latency, i.e.
Zdenek, Hlinák, Ivan, Krejcí
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Possible anxiolytic effects of taurine in the mouse elevated plus-maze
Life Sciences, 2004The effects of taurine, an inhibitory amino acid, on the behavior of male mice were examined in the elevated plus-maze test of anxiety. Acute taurine treatment (60 mg/kg, PO) significantly increased the percentage of time spent in the open arms. Moreover, when taurine was administered daily for seven days and the plus-maze test was conducted 40 minutes
Si Wei, Chen +5 more
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Effects of apomorphine on rat behavior in the elevated plus-maze
Physiology & Behavior, 2005It has been reported that novelty may evoke both an exploratory and a fear drive, thus generating behavior responding to an approach/avoidance conflict. However, not much is known about the approach component. Whereas there exists abundant evidence referring to the avoidance component as the main target for the anxiolytic action of benzodiazepines, the
Andrea Milena Becerra, Garcia +3 more
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Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze
Brain Research, 2001Naturally occurring estrogen-like molecules in plants (phytoestrogens), present via soy, in animal diets, exert many of the biological responses evoked by physiological estrogens. This study characterized the effects of dietary phytoestrogens on the expression of body weight, consummatory behavior, and anxiety (as expressed in the elevated plus-maze ...
T D, Lund, E D, Lephart
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