Brazilian Journal of Medical and Biological Research, 2013 This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1,
K.R. Serafim +3 more
doaj +3 more sources
Chronic consumption of distilled sugarcane spirit induces anxiolytic-like effects in mice
Clinics, 2011 OBJECTIVE: Chronic ethanol consumption is a major public health problem throughout the world. We investigated the anxiolytic-like effects and the possible ever injury induced by the chronic consumption of ethanol or sugarcane spirit in mice.
Maria Clecia P. Sena +5 more
doaj +1 more source
Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]
, 2017 Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M. +11 more
core +2 more sources
Journal of Visualized Experiments, 2019 The overall goal of this study is to describe the methodology of the elevated plus maze (EPM) test in combination with a video tracking software. The purpose of the method is to document the effect of various potential anxiolytic treatments on laboratory
C. Ari +5 more
semanticscholar +1 more source
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice [PDF]
, 2016 Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43).
Alfieri, Julio Armando +2 more
core +2 more sources
Administration of the antioxidant n-acetyl-cysteine in pregnant mice has long-term positive effects on metabolic and behavioral endpoints of male and female offspring prenatally exposed to a high-fat diet [PDF]
, 2018 A growing body of evidence suggests the consumption of high-fat diet (HFD) during pregnancy to model maternal obesity and the associated increase in oxidative stress (OS), might act as powerful prenatal stressors, leading to adult stress-related ...
Arese, Marzia +6 more
core +3 more sources
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition [PDF]
, 2015 The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a
Cao, Hong +4 more
core +2 more sources
Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008 Background and objectives Cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. There are also functional interactions between both cannabinoid and opioid systems. In this study we investigated the
SH Sarahroodi +3 more
doaj +1 more source
Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]
, 2016 Peer ...
Drever, Benjamin D. +7 more
core +3 more sources
Anti-anxiety Activity of Methanolic Extracts of Different Parts of Angelica archangelica Linn.
Journal of Traditional and Complementary Medicine, 2012 Angelica archangelica Linn.is a herb distributed in tropical and subtropical regions of the world. In Indian and Chinese system of medicine, it is used for nervous disorders and cerebral diseases. Previously the aqueous extract of the A. archangelica was
Dinesh Kumar, Zulfiqar Ali Bhat
doaj +1 more source