Results 251 to 260 of about 96,671 (319)

Elevated Plus Maze for Assessment of Anxiety and Memory in Rodents.

Methods in molecular biology
The elevated plus maze is the most widely used paradigm to evaluate anxiety-associated behavioral alterations in rodent models of central nervous system (CNS) disorders. Unconditioned aversive behavior for open and elevated areas is a measure of anxiety and can be assessed by the plus maze.
R. C. S. R. Danduga, P. K. Kola
semanticscholar   +3 more sources

Ethopharmacological analysis of rat behavior on the elevated plus-maze

Pharmacology Biochemistry and Behavior, 1994
Behavioral categories were measured in rats left on an elevated plus-maze for 5 min, in addition to the traditional measures. Four independent factors emerged from a factor analysis. The variables that loaded highly and positively on Factor 1, seemingly related with anxiety, were: number of entries onto open arms, time spent on open arms, percentage of
A. Cruz, A. Cruz, Fernando Frei, F. Graeff   +3 more
semanticscholar   +4 more sources

Anxiogenic stimuli in the elevated plus-maze

Pharmacology Biochemistry and Behavior, 1993
Untreated rats normally avoid the open arms of the "elevated plus-maze," preferring instead the closed arms, whereas rats treated with antianxiety drugs (e.g., diazepam) show far less open-arm avoidance. Although it has often been assumed that rats avoid the open arms because of novelty, height, or open space, the anxiogenic role of these stimuli in ...
D, Treit, J, Menard, C, Royan
openaire   +2 more sources

Elevated Plus Maze on Based Computer Vision

2007 IEEE 15th Signal Processing and Communications Applications, 2007
This paper presents a novel method for rat detection and tracking in a platform known as elevated-plus maze and for recording the rat movements as a time elapsed in specific regions in real time surveillance systems. First, the location of plus maze platform is automatically determined by using hough transform.
Mustafa Sahin, Murat Ekinci, Eyup Gedikli, Sukrucan H. Baytan   +3 more
openaire   +1 more source

Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats

Behavioural Pharmacology, 2018
Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent ‘microdosing’ (usually one-tenth of a ‘full’ active dose), with reports of long-
R. Horsley, T. Páleníček, J. Kolin, K. Valeš   +3 more
semanticscholar   +1 more source

Antianxiety effect of cannabidiol in the elevated plus-maze

Psychopharmacology, 1990
In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective.
F S, Guimarães, T M, Chiaretti, F G, Graeff, A W, Zuardi   +3 more
openaire   +2 more sources

Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze

General Pharmacology: The Vascular System, 1994
1. In order to assess the presence of anxiolytic properties in cannabidiol (CBD) derivatives HU-219, HU-252 and HU-261, these drugs were tested in rats submitted to the elevated plus-maze model of anxiety. 2. Additional groups received diazepam or CBD.
F S, Guimarães, J C, de Aguiar, R, Mechoulam, A, Breuer   +3 more
openaire   +2 more sources

Behavior ontogeny in the elevated plus‐maze: prenatal stress effects

International Journal of Developmental Neuroscience, 2006
AbstractPrenatal stress is a putative model for studying some psychopathological disorders. Indeed, submitting pregnant animals to stress leads to enhanced anxiety in the adult offspring. However, little is known about how prenatal stress effects interacts with anxiety throughout development. To study this issue, prenatally stressed rats were tested in
Celio, Estanislau, Silvio, Morato
openaire   +2 more sources

Ethopharmacological analysis of the open elevated plus-maze in mice

Behavioural Brain Research, 2013
Exposure of rodents to an open elevated plus-maze (oEPM) elicits antinociception and increases plasma corticosterone levels. However, no studies have yet assessed the defensive behaviour repertoire of animals in this modified test. In Experiment 1, factor analysis was employed to characterise the behavioural profile of mice exposed to the oEPM ...
Sorregotti, Tatiani, Mendes-Gomes, Joyce, Rico, Javier Leonardo, Rodgers, Robert John, Nunes-de-Souza, Ricardo Luiz   +4 more
openaire   +3 more sources

Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze

Journal of Neuroscience Methods, 2005
When studying functional asymmetries in normal laboratory rats, several behavioral tests have been applied and proven their utility, including turning in rotometers or open-fields, handedness in paw usage, T-maze alternation, and others. Here, we analyzed male Wistar rats in two tests, namely the elevated plus-maze and the T-maze.
Rainer K W, Schwarting, Andreas, Borta
openaire   +2 more sources