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The influence of open arm ledges and maze experience in the elevated plus-maze
Pharmacology Biochemistry and Behavior, 1996In Experiment 1, rats were tested in a plus-maze, with or without small ledges on the open arms, after injection with vehicle or chlordiazepoxide (7.5 mg/kg). They were scored either on their first or second exposure to the maze; those scored on trail 2 had received a 5-min undrugged exposure to the maze 24 h earlier.
C, Fernandes, S E, File
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Temporal structure of the rat's behavior in elevated plus maze test
Behavioural Brain Research, 2013Aim of the research was to evaluate, by means of quantitative and multivariate temporal pattern analyses, the behavior of Wistar rat in elevated plus maze (EPM) test. On the basis of an ethogram encompassing 24 behavioral elements, quantitative results showed that 130.14 ± 8.01 behavioral elements occurred in central platform and in closed arms ...
CASARRUBEA, Maurizio +6 more
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Pharmacological characterization of cannabinoids in the elevated plus maze.
The Journal of Pharmacology and Experimental Therapeutics, 1990delta 9-Tetrahydrocannabinol (delta 9-THC) induced in both rats and mice an increased aversion to the open arms of the elevated plus maze which was similar to that produced by anxiogenic agents. This effect of delta 9-THC was approximately three times greater in rats than in mice.
E S, Onaivi, M R, Green, B R, Martin
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MK-801 induced amnesia for the elevated plus-maze in mice
Behavioural Brain Research, 2002MK-801, a non-competitive NMDA receptor antagonist, has been shown to have amnesic properties in animal models. The purpose of the present study was to examine potential amnesic effects of MK-801 in mice using the modified elevated plus-maze paradigm. An animal was placed on the distal end of an open arm, and the transfer latency, i.e.
Zdenek, Hlinák, Ivan, Krejcí
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Possible anxiolytic effects of taurine in the mouse elevated plus-maze
Life Sciences, 2004The effects of taurine, an inhibitory amino acid, on the behavior of male mice were examined in the elevated plus-maze test of anxiety. Acute taurine treatment (60 mg/kg, PO) significantly increased the percentage of time spent in the open arms. Moreover, when taurine was administered daily for seven days and the plus-maze test was conducted 40 minutes
Si Wei, Chen +5 more
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Effects of apomorphine on rat behavior in the elevated plus-maze
Physiology & Behavior, 2005It has been reported that novelty may evoke both an exploratory and a fear drive, thus generating behavior responding to an approach/avoidance conflict. However, not much is known about the approach component. Whereas there exists abundant evidence referring to the avoidance component as the main target for the anxiolytic action of benzodiazepines, the
Andrea Milena Becerra, Garcia +3 more
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Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze
Brain Research, 2001Naturally occurring estrogen-like molecules in plants (phytoestrogens), present via soy, in animal diets, exert many of the biological responses evoked by physiological estrogens. This study characterized the effects of dietary phytoestrogens on the expression of body weight, consummatory behavior, and anxiety (as expressed in the elevated plus-maze ...
T D, Lund, E D, Lephart
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NeuroToxicology, 2009
Chlorpyrifos (CPF) is a broad spectrum organophosphate (OP) pesticide widely used in agriculture, industry and household. Several animal studies indicate emotional disturbances after CPF exposure, although the results are sometimes puzzling. Thus, both anxiolytic and anxiogenic effects of CPF have been reported in different animal models of anxiety ...
G A, López-Crespo +3 more
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Chlorpyrifos (CPF) is a broad spectrum organophosphate (OP) pesticide widely used in agriculture, industry and household. Several animal studies indicate emotional disturbances after CPF exposure, although the results are sometimes puzzling. Thus, both anxiolytic and anxiogenic effects of CPF have been reported in different animal models of anxiety ...
G A, López-Crespo +3 more
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Mathematical methods to model rodent behavior in the elevated plus-maze
Journal of Neuroscience Methods, 2013The elevated plus maze is a widely used experimental test to study anxiety-like rodent behavior. It is made of four arms, two open and two closed, connected at a central area forming a plus shaped maze. The whole apparatus is elevated 50 cm from the floor.
Rafael, Arantes +4 more
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Behavioural Brain Research, 2005
Prenatal stress and maternal separation are used in a large number of studies on early adversity consequences and present some similarities in their effects. The present work investigates the behavioral effects of these two procedures on two models of anxiety: the elevated plus-maze and the elevated T-maze.
Celio, Estanislau, Silvio, Morato
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Prenatal stress and maternal separation are used in a large number of studies on early adversity consequences and present some similarities in their effects. The present work investigates the behavioral effects of these two procedures on two models of anxiety: the elevated plus-maze and the elevated T-maze.
Celio, Estanislau, Silvio, Morato
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