Results 271 to 280 of about 96,671 (319)

Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus-maze

Pharmacology Biochemistry and Behavior, 2002
In rodents, prior maze experience increases open arm avoidance (OAA) and compromises the anxiolytic effects of benzodiazepines in a subsequent exposure to the elevated plus-maze (EPM), a phenomenon referred to as "one trial tolerance" (OTT). Nevertheless, a possible correlation between these intriguing events remains unclear.
L J, Bertoglio, A P, Carobrez
openaire   +2 more sources

The elevated plus maze test in mice-difficulties and solutions

International Journal of Psychophysiology, 2008
Elevated plus maze test (EPM) is one of the most widely used animal models for screening anxiolytic and anxiogenic agents. It is an exploratory-based approach-avoidance paradigm measuring nonconditioned responses. Its simplicity and relatively low cost made it essential in the preclinical phase of industrial research for central nervous system drugs ...
N. Sziray, G. Gigler, G. Levay, L.G. Harsing, I. Gacsalyi   +4 more
openaire   +1 more source

The interplay of learning and anxiety in the elevated plus-maze

Behavioural Brain Research, 1993
In naive rats benzodiazepines have clear anxiolytic effects in the elevated plus-maze, but in rats with previous plus-maze experience benzodiazepines are ineffective. This phenomenon does not depend on the drug state on trial 1 or on the inter-trial interval and generalises across mazes of different material; it is dependent on experience of the open ...
openaire   +2 more sources

Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003
dl-Tetrahydropalmatine (dl-THP), a naturally occurring alkaloid, has been intensively studied for its sedative and hypnotic effects. Putative explanation for its mechanism and target of action involves the dopaminergic neurotransmission system. In view of the close interactions between the dopaminergic and the GABAergic neurons in the amygdala ...
Huen, M, Zheng, H, Leung, WC, Xue, H, Law, SL   +4 more
openaire   +4 more sources

Ethopharmacological Analysis of 5-HT Ligands on the Rat Elevated Plus-Maze

Pharmacology Biochemistry and Behavior, 1999
The present study investigated the behavioral effects of five 5-HT agonists and antagonists in the rat elevated-plus-maze using conventional and ethologically derived measures. An anxiolytic effect of the 5-HT1A agonist ipsapirone (0.25, 0.75, and 2.25 mg/kg) was detected by risk-assessment and scanning but not by percentage of open-arm entries and ...
J, Setem, A P, Pinheiro, V A, Motta, S, Morato, A P, Cruz   +4 more
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[Assessment of anxiolytics (2)--An elevated plus-maze test].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995
When rodents are placed on an elevated plus-maze which consisted of two enclosed arms and two open arms, they enter the enclosed arms more frequently and spend more time on the enclosed arms than on the open arms since they prefer the enclosed arms to the open arms.
M, Imaizumi, S, Miyazaki
openaire   +1 more source

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Journal of Neuroscience Methods, 1985
S. Pellow, P. Chopin, S. File, M. Briley
semanticscholar   +1 more source

Feehan and Kritzer Elevated Plus Maze Data

Ethovision -generated data from longitudinal elevated plus maze testing in male and female wild type and Pink1-/- rats.
openaire   +1 more source

Pharmacology of Anxiety or Pharmacology of Elevated Plus Maze?

Biological Psychiatry, 2021
Anton Bespalov, Thomas Steckler
openaire   +2 more sources

The Elevated Plus Maze Test for Measuring Anxiety-Like Behavior in Rodents.

Methods in molecular biology, 2018
A. Kraeuter, P. Guest, Z. Sarnyai
semanticscholar   +1 more source