Results 131 to 140 of about 4,921 (214)

Evaluating the roles of drift and selection in trait loss along an elevational gradient. [PDF]

Evolution
Buysse SF, Pérez SG, Puzey JR, Garrison A, Bradburd GS, Oakley CG, Tonsor SJ, Picó FX, Josephs EB, Conner JK.   +9 more
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Canalized to heat, plastic to cold: adaptive coordination of leaf and seed strategies in populations spanning an elevational gradient. [PDF]

New Phytol
Chaves CJN, Tavares DU, Lemos-Silva IV, Bento JPSP, Vilela-Bianchini H, Aecyo P, Cacossi TC, Tavares MM, Sabino GP, Kamimura VA, Dos Santos WL, Gonçalves LN, Silva KT, Mayer JLS, Ribeiro RV, Escobar-Escobar D, Feeley KJ, Palma-Silva C.   +17 more
europepmc   +1 more source

Phenotypic plasticity of growth ring traits in Pinus hartwegii at the ends of its elevational gradient. [PDF]

Front Plant Sci, 2023
Carrillo-Arizmendi L, Vargas-Hernández JJ, Rozenberg P, Pérez-Suárez M, Martínez-Campos AR.   +4 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Rhizosphere microbial functions drive ecological stoichiometry in soils across an elevational gradient of a temperate mountain ecosystem. [PDF]

Commun Biol
Yang Y, Qiu K, Zhang Y, Cui Q, Liu W, Guo Y, Liu H, Xie Y.   +7 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Functional and Phylogenetic Structure of Forest Bird Assemblages Along an Afrotropical Elevational Gradient. [PDF]

Ecol Evol
Pernice R, Sedláček O, Albrecht T, Tomášek O, Kauzál O, Kauzálová T, Motombi FN, Ewome FL, Ferenc M, Chmel K, Mlíkovský J, Riegert J, Kamga SM, Hořák D.   +13 more
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Tree structural diversity mediates vegetation carbon storage in dry-hot valley savannas along an elevational gradient. [PDF]

Plant Divers
Li WC, Huang Q, Yang RJ, Peng ZY, Cai Q, Fang WJ, Liu WJ, Ma SH, Chen YJ, Zhang ZM.   +9 more
europepmc   +1 more source