Results 31 to 40 of about 4,921 (214)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Small mammal species richness and turnover along elevational gradient in Yulong Mountain, Yunnan, Southwest China

Ecology and Evolution, 2020
Understanding the species diversity patterns along elevational gradients is critical for biodiversity conservation in mountainous regions. We examined the elevational patterns of species richness and turnover, and evaluated the effects of spatial and ...
Zhongzheng Chen, Xueyou Li, Wenyu Song, Quan Li, Kenneth Onditi, Laxman Khanal, Xuelong Jiang   +6 more
doaj   +1 more source

Variations in Plant Richness, Biogeographical Composition, and Life Forms along an Elevational Gradient in a Mediterranean Mountain

Plants, 2021
Despite the increasing interest in elevational patterns in biodiversity, few studies have investigated variations in life forms and biogeographical composition, especially in the Mediterranean biome.
Letizia Di Biase, Loretta Pace, Cristina Mantoni, Simone Fattorini   +3 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Unraveling the Influence of Elevation on Moss Species–Area Relationships and the Effect of Spatial Scale on Elevational Richness Patterns in Mt Wutai With a Nested‐Plot Sampling Design

Ecology and Evolution
Understanding how species–area relationships (SARs) vary with elevation as well as how elevational richness patterns vary across spatial scales is critical for biodiversity conservation in montane systems.
Haozhe Wang, Fenghua Wang, Yu Zhao, Chenglong Li, Xiaowei Ma, Xiaopan Wang, Lina Zhang, De Gao   +7 more
doaj   +1 more source

Vascular Epiphyte Assemblages on Isolated Trees along an Elevational Gradient in Southwest Panama

Diversity, 2021
Ongoing destruction of tropical forests makes isolated pasture trees potentially important for the persistence of original forest dwellers such as many vascular epiphytes.
Calixto Rodríguez Quiel, Gerhard Zotz
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

House Sparrows Passer domesticus increase in body size and dorsal feather insulation along a Himalayan elevational gradient

Journal of Field Ornithology
Elevational gradients impact organisms in diverse ways because of lower temperatures and oxygen levels at higher elevations. Birds adapt to these constraints through changes in body size, plumage, metabolism, and behaviors such as elevational migration ...
Renu Bala, R Suresh Kumar, Pranav Gokhale, Dhananjai Mohan, Sahas Barve   +4 more
doaj   +1 more source

Effects of boundary constraints and climatic factors on plant diversity along an altitudinal gradient

Global Ecology and Conservation, 2019
Despite the long-standing ecological interest in elevational-diversity gradients, it remains unclear whether different life forms (trees, shrubs and herbs) show the same diversity patterns along the gradient.
Hede Gong, Tao Yu, Xing Zhang, Peng Zhang, Jin Han, Jie Gao   +5 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source