Results 121 to 130 of about 252,220 (287)
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Elevational constraints on flight efficiency shape global gradients in avian wing morphology [PDF]
Wings with an elongated shape or larger surface area are associated with increased flight efficiency in a wide range of animals from insects to birds.1,2,3,4 Inter- and intra-specific variation in these attributes of wing shape is determined by a range ...
Chenyue Yang (19868279) +4 more
core +2 more sources
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Advanced Science, EarlyView.Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang +11 more
wiley +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
The present macroecological study aims to understand the diversity and distribution patterns of zooplankton and zoobenthos species along the elevational gradients in the Himalaya.
Manish, Kumar +3 more
core +1 more source
DO BUMBLEBEES PARTITION AN ELEVATIONAL GRADIENT BY BODY SIZE?
, 2022 As the climate warms, Arctic bumblebee species face the loss of habitat and must deal with increased competition from southern species tracking their thermal and habitat niches north, for example Bombus terrestris. Previous studies demonstrate that bumblebees follow Bergmann’s rule, i.e., larger body sizes at higher latitudes, despite bumblebees not ...
openaire +2 more sources
The elevational gradient of species richness: a uniform pattern?
Ecography, 1995 The decline in species richness with increasing elevation is widely accepted as a general pattern (Table 1). In as much as the elevational gradient is often claimed to mirror the latitudinal gradient, species richness is assumed to decrease monotonically (i.e. because of reduced temperature and consequent decrease in productivity). Perhaps because such
openaire +1 more source
Does pollinator dependence decrease along elevational gradients? [PDF]
Plant Divers, 2023 Xu YW +5 more
europepmc +1 more source
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source