Results 31 to 40 of about 59,095 (264)

Second-Line Treatment of Metastatic Renal Cell Carcinoma in the Era of Predictive Biomarkers

Diagnostics, 2023
Background: Over the past few years, significant advancements have been achieved in the front-line treatment of metastatic renal cell carcinomas (mRCCs).
Andreea Ioana Parosanu, Catalin Baston, Ioana Miruna Stanciu, Cristina Florina Parlog, Cornelia Nitipir   +4 more
doaj   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Cardiovascular Mortality in Type 2 Diabetes Patients with Incident Exposure to Insulin Glargine

Journal of Diabetes Research, 2015
The study investigated the impact of insulin glargine exposure on cardiovascular mortality in type 2 diabetes patients with incident insulin initiation.
Sorin Ioacara, Cristian Guja, Aura Reghina, Sorina Martin, Anca Sirbu, Simona Fica   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Atypical Presentation of Rapidly Progressive Cutaneous Metastases of Clear Cell Renal Carcinoma: A Case Report

Medicina
Cutaneous metastases from clear cell renal carcinoma (ccRC) are uncommon and often indicate a poor prognosis. These metastases typically occur on the scalp, face, and trunk, and they can be difficult to diagnose due to their resemblance to benign ...
Carmen Andrada Iliescu, Cristina Beiu, Andreea Racoviță, Cristina-Mihaela Olaru, Irina Tudose, Andreea Vrancianu, Liliana Gabriela Popa   +6 more
doaj   +1 more source

Optic nerve assessment identifies biomarkers of axonal pathology in multiple sclerosis [PDF]

Romanian Journal of Neurology, 2012
Our aim was to identify possible correlations between physical disabilities assessed by expanded disability status score (EDSS) and neurodegenerative process measured by retinal nerve fibers thickness, and also with demyelization process measured by ...
Simona Petrescu, Alina Ciocalteu, Petru Ionescu, Gina Doinita Vanghelie, Mircea Moldovan, Nicolae Munjev, Cristina Panea, Ovidiu Bajenaru   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Management of Iatrogenic Bile-Duct Injury After Cholecystectomy, 1995–2025: Systematic Review and Meta-Analysis

Life
Iatrogenic bile duct injury (IBDI) constitutes a major complication of cholecystectomy. The optimal timing, method, and setting for definitive repair remain subjects of debate.
Catalin Piriianu, Elena-Adelina Toma, Octavian Enciu, Mugur Ardelean, Adrian Miron, Valentin Calu   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Der graben um den altar des Elias

Estudios Eclesiásticos, 1960
La tradición dice que Elías cavó una zanja alrededor del altar en el monte Carmelo (1Re 18, 29-38). Esta hipótesis no ha sido del todo aceptada por la dificultad de sus explicaciones, tanto por la causa de la excavación, como por la talla que tendría. Se
Hubert Junker
doaj