Results 61 to 70 of about 593,243 (307)

The rhizobacterial elicitor acetoin induces systemic resistance in Arabidopsis thaliana

Communicative & Integrative Biology, 2010
Majority of plant growth promoting rhizobacteria (PGPR) confer plant immunity against a wide range of foliar diseases by activating plant defences that reduce a plant’s susceptibility to pathogen attack.
T. Rudrappa, M. Biedrzycki, Sridhara G. Kunjeti, N. Donofrio, K. Czymmek, Paré Paul W., H. Bais   +6 more
semanticscholar   +1 more source

Defense response enhancement in strawberry via elicitors [PDF]

3 Biotech, 2016
في هذه الدراسة، تم إنشاء ثقافة تعليق الخلايا للفراولة (فراغاريا × أناسا)، وأصناف كاماروسا، وتشارلي الحلو. تم تحفيز الدشبذ الجنيني عن طريق حضانة أوراق اليافعين في المختبر على وسط، تحتوي على 2 ملغ/لتر من البيكلورام في الظلام. بدأت مزرعة التعليق من كالي الجنيني البالغ من العمر 4 أسابيع في وسط MS السائل مع 1 ملغ/لتر 2،4 - D و 2 ملغ/لتر بيكورام.
Gihan M. Hussein, Tarig Abdelrahman, Adel Hamdan Alwan   +2 more
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus

Frontiers in Plant Science, 2023
IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao, Juan Hao, Lijun Zheng, Lijun Zheng, Yidie Han, Yidie Han, Hongshan Zhang, Hongshan Zhang, Hongshan Zhang, Kailin Hou, Kailin Hou, Xueshuang Liang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Jiayi Qian, Jiayi Qian, Zhihao Lin, Zhihao Lin, Zitong Wang, Houqing Zeng, Houqing Zeng, Chenjia Shen, Chenjia Shen, Chenjia Shen   +24 more
doaj   +1 more source

Elicitor induced defence responses in medicago sativa [PDF]

New Phytologist, 2001
•  The effects are reported here of an elicitor prepared from liquid cultures of an isolate of Verticillium albo-atrum, which is nonpathogenic to Medicago sativa, on accumulation of H2 O2 , medicarpin, deposition of phenolic polymer and phenylalanine ammonia-lyase (PAL) activity in cultured cells of Medicago sativa L. cv. Kabul (lucerne).
M, Tang, C J, Smith
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source