Results 81 to 90 of about 34,516 (307)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]
, 2017 The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core +3 more sources
Tropospheric ozone as a fungal elicitor
Journal of Biosciences, 2009 Tropospheric ozone has been proven to trigger biochemical plant responses that are similar to the ones induced by an attack of fungal pathogens,i.e. it resembles fungal elicitors.This suggests that ozone can represent a valid tool for the study of stress responses and induction of resistance to pathogens.
openaire +2 more sources
Fungal cellulase is an elicitor but its enzymatic activity is not required for its elicitor activity [PDF]
Molecular Plant Pathology, 2014 Summary Plant‐pathogenic fungi produce cellulases. However, little information is available on cellulase as an elicitor in plant–pathogen interactions. Here, an endocellulase ( EG 1) was isolated from R ...
Yanan, Ma +6 more
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Cloning of cryptogein gene and construction of its plant expression vector
浙江大学学报. 农业与生命科学版, 2002 The cryptogein gene was obtained by PCR amplification from genomic DNA of Phytophthora cryptogea and verified by DNA sequencing. A promoter of a rice phenylalanine ammonia-lyase (PAL) gene was selected to control the expression of cryptogein gene ...
JIANG Dong-hua +2 more
doaj +1 more source
Insect-induced daidzein, formononetin and their conjugates in soybean leaves. [PDF]
, 2014 In response to attack by bacterial pathogens, soybean (Gylcine max) leaves accumulate isoflavone aglucones, isoflavone glucosides, and glyceollins. In contrast to pathogens, the dynamics of related insect-inducible metabolites in soybean leaves remain ...
Aboshi, Takako +10 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A Thioredoxin Domain-Containing Protein Interacts with Pepino mosaic virus Triple Gene Block Protein 1 [PDF]
, 2018 Pepino mosaic virus (PepMV) is a mechanically-transmitted tomato pathogen of importance worldwide. Interactions between the PepMV coat protein and triple gene block protein (TGBp1) with the host heat shock cognate protein 70 and catalase 1 (CAT1 ...
Khechmar, Souheyla +8 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source