Results 101 to 110 of about 19,305 (300)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A protein elicitor PeVn1 from Verticillium nonalfalfae HW recognized as a MAMP triggers plant immunity response

Frontiers in Plant Science
Protein elicitors can induce plant systemic resistance to pathogens. The recognition of a potential elicitor activates intracellular signaling events, leading to plant resistance against pathogens.
Ziyu Zhang, Dong Wang, Baozhu Dong, Yu Wang, Jialu Xu, Jianxiu Hao, Hongyou Zhou   +6 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

INDUCTION OF PLANT RESISTANCE TO NEMATODES SEDENTARY BIOGENIC ELICITORS

Российский паразитологический журнал, 2016
Objective of research: to study the mechanisms of induced tomato plant resistance to rootknot nematode Meloidogyne incognita and potato to cyst nematode Globodera rostochiensis.Materials and methods: The biogenic elicitors — chitosan and signal molecules
Zh. V. Udalova, S. V. Zinovieva
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Differential activation of four specific MAPK pathways by distinct elicitors

, 2000
Cardinale F, Jonak C, Ligterink W, Niehaus K, Boller T, Hirt H. Differential activation of four specific MAPK pathways by distinct elicitors. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(47):36734-36740.Plant cells respond to elicitors by inducing a variety
Boller, T, Ligterink, W, Cardinale, F, Hirt, H, Jonak, C, Niehaus, Karsten, Cardinale, Francesca   +6 more
core   +1 more source

Anaphylaxis and pregnancy: Epidemiology, elicitors, and recurrences

World Allergy Organization Journal
Anaphylaxis during pregnancy implies a risk to both mothers and newborns. However, limited data are available. Therefore, our aim is to explore patterns of hospital admissions diagnosed with anaphylaxis in pregnant women in France from 2012 to 2021, using a national hospital billing database and to evaluate potential determinants, trends and ...
Tanno, Luciana Kase, Luong, Pham Thao Van, Dieval, Megane, Dunoyer, Caroline, Di Meglio, Emma, Fuchs, Florent, Molinari, Nicolas, Annesi-Maesano, Isabella, Demoly, Pascal   +8 more
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Organic vs. Integrated-Production Agriculture Farming: Which Grapevine Stress-Responsive Genes Are Affected by the Application of Resistance Inducers and Elicitors?

Agronomy
With the rising prominence of organic farming systems in European Union countries, motivated by agricultural policies, there is pressure for effective disease management strategies.
Tomás Monteiro, Mariana Patanita, Maria do Rosário Félix, André Albuquerque, Joana A. Ribeiro, Filipa Santos, Margarida Basaloco, Augusto Maria da Rosa, Maria Doroteia Campos   +8 more
doaj   +1 more source