Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies
Advanced Healthcare Materials, EarlyView.Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best +5 more
wiley +1 more source
Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding. [PDF]
Sci RepRady MR, Mabrouk DM, Ibrahim MM.
europepmc +1 more source
Elicitor activity of cerebroside, a sphingolipid elicitor, in cell suspension cultures of rice
Elicitor activity of cerebroside, a sphingolipid elicitor, in cell suspension cultures of riceCerebrosides, compounds categorized as glycosphin-golipids, were found to occur in a wide range of phytopathogens as novel elicitors and to induce the effective disease resistance for rice plants in our previous study. Here, we showed that cerebroside elicitors lead to the accumulation of phytoalexins and pathogenesis-related (PR) protein in cell ...
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Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Advanced Healthcare Materials, EarlyView.Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
Discovery that PACAP, a mammalian neuropeptide, activates plant immunity through chemical screening. [PDF]
Front Plant SciDong G, Xu Y, Zhou L, Ye Y, He K.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Metabolomic and volatile profiling reveals defence-related effects of IbPep1 in sweet potato cell culture. [PDF]
BMC Plant BiolZhyr L, Cruz CMD, Mithöfer A.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee +10 more
wiley +1 more source
Biotic Elicitor-Driven Enhancement of In Vitro Micropropagation and Organogenesis in <i>Solanum tuberosum</i> L. cv. Fianna. [PDF]
BioTech (Basel)James-Forest M +6 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens +3 more
wiley +1 more source