Results 71 to 80 of about 33,383 (309)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Profiling of altered metabolomic states in Nicotiana tabacum cells induced by priming agents.

Frontiers in Plant Science, 2016
Metabolomics has developed into a valuable tool for advancing our understanding of plant metabolism. Plant innate immune defenses can be activated and enhanced so that, subsequent to being pre-sensitized, plants are able to launch a stronger and faster ...
Msizi Innocent Mhlongo, Paul Anton Steenkamp, Paul Anton Steenkamp, Lizelle Ann Piater, Ntakadzeni Edwin Madala, Ian A Dubery   +5 more
doaj   +1 more source

Phytophthora megakarya and Phytophthora palmivora, closely related causal agents of cacao black pod rot, underwent increases in genome sizes and gene numbers by different mechanisms [PDF]

, 2017
Phytophthora megakarya (Pmeg) and Phytophthora palmivora (Ppal) are closely related species causing cacao black pod rot. Although Ppal is a cosmopolitan pathogen, cacao is the only known host of economic importance for Pmeg.
Ali, Shahin, Amoako-Attah, Ishmael, Bailey, Bryan, Begoude, Dider, Coulibaly, Klotioloma, Guiltinan, Mark J., Kronmiller, Brent A., Kébé, Boubacar Ismaël, Lary, David J., Meinhardt, Lyndel W., Melnick, Rachel L., Shao, Jonathan, Shen, Danyu, Strem, Mary, Ten Hoopen, Gerben Martijn, Tyler, Brett, Yaw Akrofi, Andrew   +16 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Control of Bremia lactucae in Field-Grown Lettuce by DL-3-Amino-n-Butanoic Acid (BABA) [PDF]

, 2007
DL-3-amino-n-butanoic acid (BABA) was effective in controlling downy mildew incited by Bremia lactucae Regel in lettuce plants. The two isomers of BABA, DL-2-amino-n-butanoic acid and 4-amino-butanoic acid and its s-enantiomer were ineffective compares ...
Baider, Alexander, Cohen, Yigal, Gotlieb, Dror, Rubin, Evgenia   +3 more
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]

, 2013
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block, A Bombarely, A Stamatakis, AN Olsen, AO Avrova, AP Rehmany, BJ Haas, BM Tyler, Brett Tyler, C Lacomme, C Zipfel, D Chinchilla, D Darriba, D Dou, DGO Saunders, EA van der Biezen, EM Gilroy, EM Gilroy, G Fabro, H-K Yoon, Hazel McLellan, HM Nguyen, HP Nguyen, I Hein, JD Jones, JIB Bos, Jim L. Beynon, JL Dangl, Juan Morales, K Bouwmeester, L Baxter, L Deslandes, Leighton Pritchard, M Karimi, M-C Caillaud, MD Curtis, Miles R. Armstrong, MS Mukhtar, N Ishihama, NK Clay, P Chomczynski, Paul R. J. Birch, Petra C. Boevink, PJ Seo, PJ Seo, PRJ Birch, PRJ Birch, Q Wang, S Capella-Gutierrez, S Dong, S Lee, S Moller, S Puranik, S Rivas, S-G Kim, S-Y Kim, SC Whisson, SK Oh, Sonia Gomez, SR Eddy, Stephen C. Whisson, T Boller, T Hoppe, T Ren, T Ren, TO Bozkurt, V Senchou, Y Liu, Y-J Lu, Y-S Kim, Z Nimchuk   +70 more
core   +4 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Establishment of feijoa (Acca sellowiana) callus and cell suspension cultures and identification of arctigenin - a high value bioactive compound

Frontiers in Plant Science
Feijoa (Acca sellowiana (O. Berg.) Burret), also known as pineapple guava, is a member of the Myrtaceae family and is well known for its fruit. Chemical profiling of the different tissues of the feijoa plant has shown that they generate an array of ...
Sanjeev V. Raikar, Ilena Isak, Sunita Patel, Harriet L. Newson, Stefan J. Hill   +4 more
doaj   +1 more source

Influence of Chitosan, Salicylic Acid and Jasmonic Acid on Phenylpropanoid Accumulation in Germinated Buckwheat (Fagopyrum esculentum Moench)

Foods, 2019
The present study investigated the effects of jasmonic acid (JA), chitosan, and salicylic acid (SA) on the accumulation of phenolic compounds in germinated buckwheat.
Chang Ha Park, Hyeon Ji Yeo, Ye Eun Park, Se Won Chun, Yong Suk Chung, Sook Young Lee, Sang Un Park   +6 more
doaj   +1 more source