Results 71 to 80 of about 1,314,010 (307)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The Impact of Match Workload and International Travel on Injuries in Professional Men’s Football

Sports
There are concerns over the impact of the congested international match calendar on professional footballers’ physical and mental well-being, and injury susceptibility.
Steve den Hollander, Gino Kerkhoffs, Vincent Gouttebarge   +2 more
doaj   +1 more source

The metropolitan geographies of elite shopping: Mary Leigh and Roger Newdigate in Georgian London [PDF]

, 2013
The importance of London as a source of elite goods is a commonplace. Work by Berry, Walsh, Vickery and Greig has painted a vivid picture of the mechanisms through which elite women in particular sought out metropolitan suppliers. It has also suggested a
Stobart, Jon
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

A break in neoliberal ideology? : A critical analysis of Bolivian elite discourse [PDF]

, 2006
Im Dezember 2005, gewannen Evo Morales und seine Partei, die Bewegung zum Sozialismus (MAS), mit über 50 Prozent der Stimmen die Wahlen in Bolivien. Dieses war das stärkste Wahlergebnis einer Partei seit Einführung der Demokratie 1982.
Schmidt, Marión C.
core  

Achievement Goals, Competition Appraisals, and the Well- and Ill-Being of Elite Youth Soccer Players Over Two Competitive Seasons [PDF]

, 2010
Grounded in the 2 × 2 achievement goal framework (Elliot & McGregor, 2001),the purpose of this study was to investigate the temporal relationships between achievement goals, competition appraisals and indices of psychological and emotional welfare among ...
Adie, James W, Duda, Joan L, Ntoumanis, Nikos   +2 more
core   +2 more sources

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Culture change in elite sport performance teams: Examining and advancing effectiveness in the new era [PDF]

, 2012
Reflecting the importance of optimizing culture for elite teams, Fletcher and Arnold (2011) recently suggested the need for expertise in culture change. Acknowledging the dearth of literature on the specific process, however, the potential effectiveness ...
Andrew Cruickshank, Balogun J., Bowes I., Carron A. V., Chelladurai P., Cruickshank A., Dave Collins, Dickinson M., Fletcher D., Gould D., Hansen J., Holt N. L., Holt N. L., Jones R. L., Kim W., Kotter J. P., League Managers Association, MacPherson A. C., McKay J., Myers I. B., Northouse P. G., Olympiou A., Pain M. A., Patton M. Q., Quested E., Railo W., Reid C., Romand P., Samuel R. D., San-Fu K., Schein E. H., Schroeder P. J., Sisjord M. K., Sénecal J., Timson S., Vaughan M., Warriner K., Windsor P. M., Zinser L., Zinser L.   +39 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Elite Capture or Capture Elites? Lessons from the ‘Counter-elite’ and ‘Co-opt-elite’ Approaches in Bangladesh and Ghana [PDF]

Community-based development has been criticized for its inadequate understanding of power relationships at the local level, which thus leaves room for elite capture.
Wong, Sam
core