Results 141 to 150 of about 1,086 (251)

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Stable isotope evidence for the participation of commoners in Inka khipu production. [PDF]

Sci Adv
Hyland S, Lee K, Koon H, Laukkanen S, Spindler L.   +4 more
europepmc   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Demography and life histories across the Roman frontier in Germany 400-700 CE. [PDF]

Nature
Blöcher J, Vallini L, Velte M, Eckel R, Guyon L, Winkelbach L, Thomas MG, Gharehbaghi N, Mitchell CT, Schümann J, Köhler S, Seyr E, Krichel K, Rau S, Hirsch J, Duras J, Cloarec-Pioffet P, Füglistaler A, Klement K, Wilkenhöner M, Vetterdietz L, Gentilin F, Müller M, Mücke AL, Zedda N, Tawfik Y, Saal E, McGlynn G, Bramanti B, Orschiedt J, Molitor R, Fliß B, Spazier I, Shankland D, Vetterling C, Karpf K, Planert V, Hölzl S, Codreanu-Windauer S, Quast D, Mikić I, Fiedler S, Päffgen B, Brami M, Richter T, Chaix R, Brather-Walter S, Steffens P, Marquart M, Becker T, Haberstroh J, Meier M, Schmidt-Hofner S, Brather S, Harbeck M, Patzold S, Wegmann D, Burger J.   +57 more
europepmc   +1 more source

Trends in publicly subsidized and private access to GLP‐1 medicines indicated for type 2 diabetes in Australia, 2020–2025

British Journal of Clinical Pharmacology, EarlyView.
Aims GLP‐1 medicines provide substantial cardio‐renal benefits for type 2 diabetes (T2D) and are increasingly used for weight loss. Most high‐income countries subsidize access for T2D with restrictions; use outside of these restrictions occurs through private prescriptions. Despite strong consumer demand, the extent of private access to GLP‐1 medicines
Michael O. Falster, Juliana de Oliveira Costa, Tamara Y. Milder, Joanne Carson, Cade Shadbolt, Brendon L. Neuen, Clare Arnott, Andrew Wilson, Min Jun, Nicole Pratt, Sallie‐Anne Pearson   +10 more
wiley   +1 more source

Genetic history of Scythia. [PDF]

Sci Adv
Andreeva TV, Soshkina AD, Gusev FE, Malyarchuk AB, Dotsenko GS, Dudko NA, Plotnikova MY, Kunizheva SS, Manakhov AD, Ustkachkintseva TV, Protasova MS, Volodin SA, Buzhilova AP, Razuvaev YD, Berezina NY, Berezin YB, Kantorovich AR, Maslov VE, Barinov DG, Dobrovolskaya MV, Rogaev EI.   +20 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Ancient genomes reveal trans-Eurasian connections between the European Huns and the Xiongnu Empire. [PDF]

Proc Natl Acad Sci U S A
Gnecchi-Ruscone GA, Rácz Z, Liccardo S, Lee J, Huang Y, Traverso L, Radzevičiūtė R, Hajnal Z, Szécsényi-Nagy A, Gyuris B, Mateovics-László O, Bernert Z, Szeniczey T, Hajdu T, Mészáros B, Bálint M, Mende BG, Miller B, Samashev Z, Childebayeva A, Djansugurova L, Geary P, Ringbauer H, Vida T, Jeong C, Pohl W, Krause J, Hofmanová Z.   +27 more
europepmc   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Family relations of Moche elite burials on the North Coast of Peru (~500 CE): Analyses of the Señora de Cao and relatives. [PDF]

Proc Natl Acad Sci U S A
Quilter J, Harkins K, Fanco Jordan R, Marsh E, Prieto G, Verano J, LeBlanc S, Broomandkhoshbacht N, Krigbaum J, Fehren-Schmitz L.   +9 more
europepmc   +1 more source