Results 51 to 60 of about 30,633 (317)

A model balancing cooperation and competition explains our right-handed world and the dominance of left-handed athletes [PDF]

Journal of the Royal Society Interface 9, 2718-2722 (2012), 2011
An overwhelming majority of humans are right-handed. Numerous explanations for individual handedness have been proposed, but this population-level handedness remains puzzling. Here we use a minimal mathematical model to explain this population-level hand preference as an evolved balance between cooperative and competitive pressures in human ...
arxiv   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Exploratory analysis of factors affecting on elite sport policy agenda setting phrase: Korean policies for elite sport athlete identification and development [PDF]

Cheyuk gwahag yeon-gu, 2020
Purpose This research aims to find out factors affecting policy at the agenda setting phrase. In order to analyze, Multiple Streams Framework(MSF) was adopted. Based on the frame, policy problem stream, policy alternative stream, political stream, window
Jeehyun Kang, Jounghwa Son, Hojin Shin, Kisung Kwon   +3 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

A Long-Term Study of Aerobic Performance in Elite Cross-Country Skiers: How Age and Sex Influence Career Development

Current Issues in Sport Science
Introduction Elite cross-country (XC) skiers undergo standardized testing to monitor their performance development and to calibrate training prescriptions.
Elias Bucher, Jon P. Wehrlin, Grégoire P. Millet, Thomas Steiner   +3 more
doaj   +1 more source

The Role of Biomarkers in Elite Sports

Balneo and PRM Research Journal, 2023
Biomarkers have emerged as valuable tools in the realm of elite sports, providing objective measures of athletes' physiological responses and potential for performance optimization. This article review delves into the significance and implications of biomarkers in elite sports, emphasizing their crucial role in supporting athletes' training, recovery ...
Lucreția Anghel, Tudor Vladimir Gurau, Gabriela Gurau, Carmina Liana Mușat, Doina Carina Voinescu, Ilie Onu, Mariana Cordun, Corneliu-Mircea Codreanu, Daniel Andrei Iordan   +8 more
openaire   +2 more sources

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Inferring Player Location in Sports Matches: Multi-Agent Spatial Imputation from Limited Observations [PDF]

arXiv, 2023
Understanding agent behaviour in Multi-Agent Systems (MAS) is an important problem in domains such as autonomous driving, disaster response, and sports analytics. Existing MAS problems typically use uniform timesteps with observations for all agents. In this work, we analyse the problem of agent location imputation, specifically posed in environments ...
arxiv  

Quantifying human performance in chess [PDF]

arXiv, 2022
From sports to science, the recent availability of large-scale data has allowed to gain insights on the drivers of human innovation and success in a variety of domains. Here we quantify human performance in the popular game of chess by leveraging a very large dataset comprising of over 120 million games between almost 1 million players.
arxiv