Results 201 to 210 of about 18,479 (265)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Varieties of Economic Elites? Preliminary Results From the World Elite Database (WED). [PDF]

Br J Sociol
Bühlmann F, Christesen CA, Cousin B, Denord F, Ellersgaard CH, Lagneau-Ymonet P, Larsen AG, Savage M, Thine S, Young K, Araujo P, Arrigoni P, Atria J, Benz P, Behr J, Botelho MDC, Butt A, Casanova P, Clemente-Casinhas L, Castellani A, Cescon F, Dagnes J, Debska H, Delval AS, Dragun V, Egas A, Emilsson K, Fan X, Fu F, Gentile J, Gomes O, Gronwald V, Heredia M, Hjellbrekke J, Honório J, Huang J, Inkley J, Johansson H, Koiranen I, Koivula A, Kuusela H, Levita G, Ling C, Lu P, Lukas M, Lunding J, Mahmoudzadeh M, McQuade S, Méndez ML, Nunes N, O'Brien S, Otero G, Pagnini M, Pelfini A, Pereira J, Roa C, Rossier T, Saga ML, Santana D, Schneickert C, Schimpfössl E, Schoenberger F, Solipa I, Trembaczowski Ł, Toft M, Vale S, Vasconcelos P, Velazco JQ, Warczok T, Yu X.   +69 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Manganese-catalyzed dehydroxyamination of catechols for the synthesis of redox-active and heterocyclic scaffolds. [PDF]

RSC Adv
Naseri Motlagh Z, Aboonajmi J, Panahi F, Khalvati L, Sharghi H.   +4 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Kaempferol Attenuates Oxidative Stress-Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis. [PDF]

Immun Inflamm Dis
Luo C, Yan J, Shen Y, Sun Z, Xiao X.
europepmc   +1 more source

The crisis of public trust and legitimacy in public health: being successful in a world in turmoil. [PDF]

J Public Health (Oxf)
Jennings B, Gostin LO.
europepmc   +1 more source

Sovietization of sports in Czechoslovakia and the establishment of the institute of physical education and sport (1948-1953). [PDF]

Front Sports Act Living
Waic M, Pechman V.
europepmc   +1 more source

Advanced Electrochemical C-C Bond Formation Using a Michael-Type Nozaki-Hiyama-Kishi (NHK) Reaction. [PDF]

ACS Omega
Torabi S, Jamshidi M, Khazalpour S.
europepmc   +1 more source

From decolonizing global health to neo-colonization by local elites: From the frying pan into the fire. [PDF]

PLOS Glob Public Health
Zadey S, Sharma D.
europepmc   +1 more source