Results 221 to 230 of about 60,063 (305)

Incorporating burn probability into spatial prioritization of woodland caribou habitat restoration

open access: yesRestoration Ecology, EarlyView.
Abstract Introduction Habitat disturbance is a major driver of population declines of woodland caribou in Canada. Habitat restoration is a critical component of a successful, long‐term approach to caribou recovery; however, with limited resources, it is important to target areas where restoration efforts will provide maximum benefits to caribou.
James C. Maltman   +5 more
wiley   +1 more source

Restoration and rehabilitation of floodplain wetlands: a systematic, global review of restoration options and their outcomes

open access: yesRestoration Ecology, EarlyView.
Abstract Introduction Floodplain wetlands are vitally important, highly productive, and biodiverse ecosystems. Species dependent on them are facing a range of threats including water extraction, habitat degradation, invasive species, and shifting climates.
Sally Maxwell   +4 more
wiley   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto   +7 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve   +11 more
wiley   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild   +3 more
wiley   +1 more source

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