Results 241 to 250 of about 19,915 (293)

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

Symmetry Breaking in Meniscus Splitting: Effects of Boundary Conditions and Polymeric Membrane Growth

open access: yesAdvanced Science, EarlyView.
Meniscus splitting in the drying of a viscous polymer dispersion is investigated by focusing on nucleation of multiple nuclei with symmetry breaking and asynchronous nucleus formation. Controlled by spatial boundaries, the first nucleus is generated at a position shifted away from the space center and strongly facilitates the asynchronous second ...
Thi Kim Loc Nguyen   +4 more
wiley   +1 more source

Interfacial Polarization Switching in Al0.92Sc0.08N/GaN Heterostructures Grown by Sputter Epitaxy

open access: yesAdvanced Science, EarlyView.
Understanding the structural and electronic interface characteristics of ferroelectric Al1‐xScxN/GaN heterostructures is crucial for the development of novel transistor structures with integrated ferroelectric functionality. In this article, Niklas Wolff and co‐workers report on the interfacial switching mechanisms and reveal atomic and electronic ...
Niklas Wolff   +6 more
wiley   +1 more source

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

open access: yesAdvanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn   +6 more
wiley   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

open access: yesAdvanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong   +12 more
wiley   +1 more source

Enhancing IoT security with a DNA-based lightweight cryptography system. [PDF]

open access: yesSci Rep
Aqeel S   +4 more
europepmc   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

open access: yesAdvanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang   +13 more
wiley   +1 more source

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