Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
Optical wave propagation in magneto-optic waveguides with generalized anti-cubic model. [PDF]
Sci ProgBaber MZ +4 more
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Dynamical analysis and soliton solutions to (3+1)-dimensional extended quantum nonlinear Zakharov-Kuznetsov equation. [PDF]
Sci RepFatima M +6 more
europepmc +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Linear stability and dispersive soliton propagation in nonlinear media subject to parabolic phase modulation. [PDF]
Sci RepMorgan M, Ahmed HM, Sayed M, Soliman M.
europepmc +1 more source
Backbone‐Length‐Optimized Inhibitors Deliver Long‐Retention Selectivity in Area‐Selective ALD of VO2
Advanced Science, EarlyView.Area‐selective VO2 ALD is found to depend critically on inhibitor backbone length, which governs physisorption, chemisorption stability, and packing efficiency in a coupled manner. An intermediate backbone‐length achieves the best long‐retention selectivity, establishing a chemically and geometrically grounded design principle for small‐molecule ...
Hae Lin Yang +9 more
wiley +1 more source
Advanced soliton structures and elliptic wave patterns in a sixth-order nonlinear Schrödinger equation using improved modified extended tanh function method. [PDF]
Sci RepFahim MM, Ahmed HM, Dib KA, Samir I.
europepmc +1 more source
Advanced Science, EarlyView.We present the MyoRobot 3.0, an advanced platform that combines high‐resolution imaging with automated mechanical testing to improve the accuracy of single muscle fibre analysis. The system tracks fibre diameter changes during stretch, preventing major stress miscalculations.
Michael Haug +5 more
wiley +1 more source
A Method for Continuous Dual-Offline Payment of Cryptocurrency Based on Asset Credentials. [PDF]
Sensors (Basel)Si H +5 more
europepmc +1 more source