A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg +16 more
wiley +1 more source
Periodic structures of solitons and shock wave solutions in the fractional nonlinear Shynaray-IIA equation via a generalized analytical method. [PDF]
Iqbal M +7 more
europepmc +1 more source
Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals
Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui +7 more
wiley +1 more source
<i>Euonymus maotaiensis</i> M.T.An & Xu Wu, sp. nov., a new species of <i>Euonymus</i> (Celastraceae) from southwest China. [PDF]
Wu X, Liu F, An MT, Yu JH, Yang WY.
europepmc +1 more source
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun +13 more
wiley +1 more source
Butterworth Filtering at 500 Hz Optimizes PPG-Based Heart Rate Variability Analysis for Wearable Devices: A Comparative Study. [PDF]
Abdrasulova N +3 more
europepmc +1 more source
Cellular forces are traditionally inferred from displacement measurements, which lack rotational information and are constrained by linear model assumptions. This work replaces displacement with rotational angle for the fundamental mechanical readout.
Linjie Ma +8 more
wiley +1 more source
Innovative solutions for lossy nonlinear transmission lines model using a modified extended mapping approach with fractional effects. [PDF]
Hussein HH, Alexan W, Kandil SA.
europepmc +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
<i>Ceropegia gengmaensis</i> (Apocynaceae), a new species from Yunnan, China. [PDF]
Luo PR +7 more
europepmc +1 more source

