Results 271 to 280 of about 22,885,588 (357)

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

open access: yesAdvanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim   +4 more
wiley   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

open access: yesAdvanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale   +6 more
wiley   +1 more source

Compressive sensing techniques based on secure data aggregation in WSNs. [PDF]

open access: yesSci Rep
Madkour ME   +5 more
europepmc   +1 more source

Determination of the Exchange Current Density at Lithium │ Polymer Electrolyte Interfaces

open access: yesAdvanced Science, EarlyView.
This work presents a comprehensively validated method to determine the exchange current density (j0) at the interface of lithium metal and polymer electrolytes by combining electrochemical impedance spectroscopy with Bayesian inference and distribution of relaxation times analyses to successfully deconvolute solid electrolyte interphase and charge ...
Katrin Geng   +4 more
wiley   +1 more source

IBS-ECDHE: A blockchain-enhanced lightweight protocol for secure cloud-IoT in biomedical HCPS. [PDF]

open access: yesComput Struct Biotechnol J
Rehman AU   +6 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

open access: yesAdvanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du   +6 more
wiley   +1 more source

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