Renal protective effect of ellipticine against streptozotocin induced diabetic nephropathy in rats via suppression of oxidative stress and inflammatory mediator [PDF]
Acta Cirúrgica Brasileira, 2023 Purpose: Diabetes mellitus is a serious health problem worldwide, and diabetic nephropathy is the complication. The diabetic nephropathy considerably enhances the oxidative stress, glycation, lipid parameters and inflammatory reaction.
Jun Li +6 more
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The Role of V-ATPase ATP6V0D1 Subunit in Chemoresistance and Ellipticine-Induced Cytoplasmic Vacuolation in Neuroblastoma Cells [PDF]
Molecular & Cellular OncologyDrug resistance remains a major obstacle in neuroblastoma treatment. Lysosomal sequestration, facilitated by the V-ATPase proton pump, is one of the mechanisms of chemoresistance. Overexpression of the ATP6V0D1 subunit of V-ATPase, previously reported in
M Rychla +4 more
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Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities [PDF]
Nature CommunicationsAzole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11
Wanqian Li +5 more
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The role of reactive oxygen species in the pathogenesis and treatment of endometrial cancer [PDF]
Frontiers in MedicineReactive oxygen species (ROS) play dual roles in the pathophysiology of endometrial cancer (EC). Oxidative stress induced by ROS can promote the survival and proliferation of cancer cells, whereas excessive accumulation of ROS can lead to various forms ...
Jeongmin Lee +10 more
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In silico exploration of anti-prostate cancer compounds from differential expressed genes [PDF]
BMC UrologyProstate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize computational methods to explore potential anti-PCa compounds based on differentially expressed genes (DEGs ...
Basiru Olaitan Ajiboye +7 more
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Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway [PDF]
Cell & BioscienceBackground Ototoxicity is a major side effect of many broadly used aminoglycoside antibiotics (AGs) and no FDA-approved otoprotective drug is available currently.
Yipu Fan +3 more
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Indonesian Journal of Pharmacy, 2021 Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole), an alkaloid isolated from plants Ochrosia elliptica, showed anticancer activity. A previous study demonstrated that ellipticine exhibited a reduction of the proliferation and self-renewal ability of ...
Adam Hermawan, Herwandhani Putri
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Sequence effect of self-assembling peptides on the complexation and in vitro delivery of the hydrophobic anticancer drug ellipticine. [PDF]
PLoS ONE, 2008 A special class of self-assembling peptides has been found to be capable of stabilizing the hydrophobic anticancer agent ellipticine in aqueous solution. Here we study the effect of peptide sequence on the complex formation and its anticancer activity in
Shan Yu Fung, Hong Yang, P Chen
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A Nitrocarbazole as a New Microtubule-Targeting Agent in Breast Cancer Treatment
Applied Sciences, 2021 Breast cancer is still considered a high-incidence disease, and numerous are the research efforts for the development of new useful and effective therapies.
Maria Stefania Sinicropi +11 more
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Frontiers in Molecular Biosciences, 2022 The BCL2L1 gene expresses two isoforms of Bcl-x protein via the use of either of two alternative 5′ splice sites (5′ss) in exon 2. These proteins have antagonistic actions, Bcl-XL being anti-apoptotic and Bcl-XS pro-apoptotic.
Mohammed Bhogadia +9 more
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