Results 91 to 100 of about 3,943 (230)
Memorias do Instituto Oswaldo Cruz, 2007 In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae)
Valter F de Andrade-Neto +15 more
doaj
mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity [PDF]
, 2006 Type II Human DNA Topoisomerases (topos II) play an essential role in DNA replication and transcription and are important targets for cancer chemotherapeutic drugs.
Gilroy, Kathryn +4 more
core +3 more sources
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Dynamin‐related protein 1 (Drp1) is a cytosolic protein that regulates mitochondrial fission. Heart ischemia/reperfusion (IR) injury results in Drp1 translocation to the mitochondrial outer mitochondrial membrane, mitochondrial swelling, and opening of the mitochondrial permeability transition pore (MPTP) associated with calcium overload, cytochrome C ...
Lin Piao +9 more
wiley +1 more source
The structural basis of actinomycin D–bindinginduces nucleotide flipping out, a sharp bendand a left-handed twist in CGG triplet repeats [PDF]
, 2013 The potent anticancer drug actinomycin D (ActD)functions by intercalating into DNA at GpC sites,thereby interrupting essential biological processesincluding replication and transcription.
Chien-Ying Chuang +3 more
core +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.Background. The emergence of drug‐resistant parasites impedes disease management and eradication efforts. Hence, a reinvigorated attempt to search for potent lead compounds in the mangroves is imperative. Aim. This study evaluates in vitro antiplasmodial activity, antioxidant properties, and cytotoxicity of A. africana leaf alkaloidal extracts. Methods.
Mustapha A. Ahmed +9 more
wiley +1 more source
Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects? [PDF]
, 2015 Due to the enormous variety of phytochemicals present in plants, their extracts have been used for centuries in the treatment of innumerous diseases, being perceived as an invaluable source of medicines for humans.
Barreira, J. C. M. +7 more
core +3 more sources
Sinteza, karakterizacija i antimikrobni učinak derivata karbazola [PDF]
, 2006 The reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with paraformaldehyde and ethylenediamine yielded N,N\u27-bis(1,2,3,4-tetrahydrocarbazol-1-ylidene)ethane-1,2-diamines (2a-e). Here, like in another similar attempt of replacing ethylenediamine by
ARPUTHARAJ EBENEZER MARTIN +1 more
core
Mycorrhizal fungi were more effective than zeolites in increasing the growth of non-irrigated young olive trees [PDF]
, 2020 Four soil treatments, consisting of two commercial mycorrhizal fungi, one zeolite and an untreated control, were arranged in a factorial design with two foliar fertilization treatments, a foliar spray and a control to study the effects of commercial ...
Arrobas, Margarida +8 more
core +1 more source
The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds [PDF]
, 2015 The Euterpe oleracea Mart. (açaí) is a plant from the Amazon region, classified as "super fruit" because of its various functional properties. However, limited investigation has been performed on açaí by-products, such as seeds.
Abreu +31 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies. They target several cellular key-points,
Maria Stefania Sinicropi +11 more
doaj +1 more source