New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies [PDF]
, 2011 Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide [1]. HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed.
Abreu, Rui M.V. +5 more
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Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate [PDF]
, 2016 Sucrose octa(N-ethyl)carbamate was synthesized directly from sucrose and ethyl isocyanate, and its structure was confirmed by various analytical methods, such as 1H and 13C NMR, FTIR, m.p., MS, and optical rotation.
Barros, M. Teresa +5 more
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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint [PDF]
, 2018 Summary Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is ...
Kucerova, Alena +6 more
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Gene cloning and expression profile of a novel carotenoid hydroxylase (CYP97C) from the green alga Haematococcus pluvialis [PDF]
, 2014 A full-length complementary DNA (cDNA) sequence of epsilon-ring CHY (designated Haecyp97c) was cloned from the green alga Haematococcus pluvialis by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends methods ...
Cui, Hongli +8 more
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Chemical characterization and bioactive properties of Prunus avium L.: The widely studied fruits and the unexplored stems [PDF]
, 2015 The aim of this study was to characterize sweet cherry regarding nutritional composition of the fruits, and individual phytochemicals and bioactive properties of fruits and stems.
Barros, Lillian +6 more
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Unveiling interactions between DNA and cytotoxic 2-arylpiperidinyl-1,4-naphthoquinone derivatives: A combined electrochemical and computational study [PDF]
, 2018 Indexación: Scopus.Three 2-arylpiperidinyl-1,4-naphthoquinone derivatives were synthesized and evaluated in vitro to determine their cytotoxicity on cancer and normal cell lines.
Canales, C. +4 more
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Frontiers in Cell and Developmental Biology, 2019 Fusobacterium nucleatum (F. nucleatum) is a crucial periodontal pathogen and human gingival fibroblasts (GFs) are the first line of defense against oral pathogens.
Wenyan Kang +13 more
doaj +1 more source
Melissa officinalis L. decoctions as functional beverages: a bioactive approach and chemical characterization [PDF]
, 2015 Lemon balm (Melissa officinalis L.) is a member of the Lamiaceae family with a long story of human consumption. It has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes.
Barros, Lillian +7 more
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Bioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative study [PDF]
, 2013 Arbutus unedo, Prunus spinosa, Rosa micrantha and Rosa canina are good sources of phenolic compounds, including anthocyanins. These compounds have potent antioxidant properties, which have been related to anticancer activity.
Barros, Lillian +5 more
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Chemical composition of wild and commercial Achillea millefolium L. and bioactivity of the methanolic extract, infusion and decoction [PDF]
, 2013 Medicinal plants used in folk medicine are being increasingly studied and used on pharmaceutical, food and nutraceutical fields. Herein, wild and commercial samples of Achillea millefolium L.
Alves, Rita C. +8 more
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