Results 171 to 180 of about 3,943 (230)

Regioselective Synthesis of Ellipticine

Helvetica Chimica Acta, 2006
An eight-step synthesis of the tetracyclic pyridocarbazole alkaloid ellipticine (= 5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 1a) in an overall yield of 13% is reported, starting from 4,7-dimethyl-1H-indene. Key steps were iodination, Suzuki coupling, reductive cyclization, DDQ oxidation, and heterocyclization under loss of H2O.
Tse-Lok Ho, Sheng-Ying Hsieh
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Ellipticine derivatives interact with muscarinic receptors

Biochemical Pharmacology, 1985
Ellipticine derivatives or analogues, tetracyclic alkaloids used in human cancer treatment, have been evaluated with regard to their interaction with several neurotransmitter receptors, in order to explain or to predict the side effects which occur in man.
G F, Alberici, J M, Bidart, P, Moingeon, S, Pailler, J M, Mondesir, A, Goodman, C, Bohuon   +6 more
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Synthetic Optimization of Ellipticine and Antitumor Activity of Novel Hexacyclic Derivatives of Ellipticine

Current Pharmaceutical Design, 2019
Background: For decades, a great deal of research work has been done to synthesize ellipticine and its derivatives because of their potential antitumor properties and anti-HIV activities. However, the resonance structures in different media, a low level of solubility at physiological pH and systemic toxicity have prevented the use of ellipticine as a ...
Jingjing, Lin, Mei, Tang, Ru, Zhao, Qianqian, Du, Longying, Shen, Guohua, Du, Yafen, Zhang, Yan, Li, Xiandao, Pan   +8 more
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ChemInform Abstract: ELLIPTICINE DERIVATIVES

Chemischer Informationsdienst, 1975
AbstractDie Indole (I) werden mit 2,5‐Hexandion (II) zu den Carbazolen (III) kondensiert, zu (IV) formyliert und dann über die Schiffschen Basen (V) bzw. über (VII) in (VI) übergeführt.
R. W. GUTHRIE, A. BROSSI, F. A. MENNONA, J. G. MULLIN, R. W. KIERSTEAD, E. GRUNBERG   +5 more
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The development of VIP–ellipticine conjugates

Regulatory Peptides, 2004
The mechanism by which vasoactive intestinal peptide (VIP)-ellipticine (E) conjugates are cytotoxic for human lung cancer cells was investigated. VIP-alanyl-leucyl-alanyl-leucyl-alanine (ALALA)-E and VIP-leucyl-alanyl-leucyl-alanine (LALA)-E inhibited (125)I-VIP binding to NCI-H1299 cells with an IC50 values of 0.5 and 0.1 microM, respectively.
Terry W, Moody, Gregory, Czerwinski, Nadia I, Tarasova, Deborah L, Moody, Christopher J, Michejda   +4 more
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Cardiovascular Activity of 9-Hydroxy-ellipticine

Pharmacology, 1976
The cardiovascular activity of 9-hydroxy-ellipticine (9-OH-E) has been studied on anaesthetized dogs. The drug has been administered intravenously in one dose ranging from 1 to 10 mg/kg. The variations in the myocardial contractility, the systemic haemodynamics, the respiration and the general metabolism of the anaesthetized dogs were studied to make ...
P H, Chanh, N D, Xuong, J B, Le Pecq, C, Paoletti   +3 more
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Stimulation of Suicidal Erythrocyte Death by Ellipticine

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractEllipticine is a potent antineoplastic alkaloid effective in part by triggering apoptosis. Mechanisms involved in ellipticine‐induced apoptosis include mitochondrial depolarization and DNA damage. Erythrocytes lack mitochondria and nuclei but may nevertheless enter suicidal death or eryptosis, which is characterized by cell shrinkage and ...
Calabrò S., Alzoubi K., Bissinger R., FAGGIO, Caterina, Lang F.   +4 more
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Ellipticine, uleine, apparicine, and related alkaloids

2001
Publisher Summary This chapter reviews the indole alkaloids that have, in common, the absence of the two-carbon side-chain of the biosynthetic precursor tryptophan—that is, the two carbons (C-5 and C-6) that normally link the indole β-position (C-7) to the non-aromatic nitrogen, though in some, a one-carbon residue remains. This chapter discusses the
M, Alvarez, J A, Joule
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ChemInform Abstract: SYNTHESIS OF ELLIPTICINE

Chemischer Informationsdienst, 1984
AbstractAus der Indolylketocarbonsäure (I) entstehen das Reduktionsprodukt (IIa) und der Ester (IIb), der mit 3‐AcetyI‐pyridin, HBr und Methanol zu (III) kondensiert, zu (IV) methyliert und zum Dihydroderivat (V) reduziert wird.
D. D. WELLER, D. W. FORD
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ChemInform Abstract: NUCLEOSIDES OF ELLIPTICINE

Chemischer Informationsdienst, 1976
AbstractVon Ellipticin (Ia) bzw. seinem Acetoxyderivat (Ib) werden durch sukzessive Reaktion mit NaH [→(II)] und der Acetochlor‐xylopyra‐ nose (III) die Nucleoside (IVa) bzw. (IVb) dargestellt.
MICHEL BESSODES, NGUYEN DAT‐XUONG NGUYEN DAT‐XUONG, KOSTAS ANTONAKIS   +2 more
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