Results 181 to 190 of about 3,943 (230)
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Short, flexible synthesis of ellipticine
Journal of the Chemical Society, Chemical Communications, 1979Ellipticine has been synthesised from 1-phenyl-sulphonylindol-2-yl 3-acetylpyridin-4-yl ketone by introducing the C-5-methyl via a Wittig reaction and catalytic reduction after selective protection of the acetyl carbonyl; acidic removal of the acetal group then led directly to the alkaloid.
Deryck A. Taylor, John A. Joule
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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1983
The biliary and urinary excretion of 9-methoxyellipticine in Rats yield the 0-demethylated metabolite 9-hydroxyellipticine, partly present as the glucuronide. Whole blood kinetics of 9-methoxyellipticine in Rabbits following a single i.v. administration is extremely fast, but is deeply modified after repeated dosage.
P, Lecointe, A, Puget
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The biliary and urinary excretion of 9-methoxyellipticine in Rats yield the 0-demethylated metabolite 9-hydroxyellipticine, partly present as the glucuronide. Whole blood kinetics of 9-methoxyellipticine in Rabbits following a single i.v. administration is extremely fast, but is deeply modified after repeated dosage.
P, Lecointe, A, Puget
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Extending Natures Leads: The Anticancer Agent Ellipticine
Current Medicinal Chemistry-Anti-Cancer Agents, 2004The natural plant product ellipticine was isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. This compound was found to be an extremely promising anticancer drug. The planar polycyclic structure was found to interact with DNA through intercalation, exhibiting a high DNA binding affinity (10(6) M(-1)).
Nichola C, Garbett, David E, Graves
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Journal of the Chemical Society, Perkin Transactions 1, 1992
Two linear isomers of the parent 5,11-dimethyl-6H-pyrido[4,3-b]carbazole ellipticine 1a, belonging to the 6H- and 10H-pyridocarbazoles series and their methoxylated derivatives, have been synthesized by three different methods using the Skraup reaction and the Fischer–Borsche cyclization.
Giovanni Alunni-Bistocchi +8 more
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Two linear isomers of the parent 5,11-dimethyl-6H-pyrido[4,3-b]carbazole ellipticine 1a, belonging to the 6H- and 10H-pyridocarbazoles series and their methoxylated derivatives, have been synthesized by three different methods using the Skraup reaction and the Fischer–Borsche cyclization.
Giovanni Alunni-Bistocchi +8 more
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Electrochemical behavior of ellipticine derivatives
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1980Abstract The electrochemical one-electron oxidation of 9-hydroxy-ellipticinium cations at a platinum electrode has been examined with particular attention to the thermodynamic redox potential and to the dimerization rate of the radical species produced.
J. Moiroux, A.M. Armbruster
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Il Farmaco; edizione scientifica, 1982
The synthesis of 8-nitro ellipticine starting from 6-nitro indole is reported. It is the first derivative of ellipticine substituted in position 8 obtained by total synthesis. In contrast to 9-nitro ellipticine the 8-nitro derivative could until now not be reduced to 8-amino ellipticine. To obtain the latter it was intended to arylate an enamine of the
C, Gansser, X, Lévque, M, Plat, C, Viel
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The synthesis of 8-nitro ellipticine starting from 6-nitro indole is reported. It is the first derivative of ellipticine substituted in position 8 obtained by total synthesis. In contrast to 9-nitro ellipticine the 8-nitro derivative could until now not be reduced to 8-amino ellipticine. To obtain the latter it was intended to arylate an enamine of the
C, Gansser, X, Lévque, M, Plat, C, Viel
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Tetrahedron, 1961
Abstract Three alkaloids named in the title were isolated from the Peruvian plant “Quillo-bordon.” The structures assigned were confirmed by partial syntheses.
G. Büchi, Dana W. Mayo, F.A. Hochstein
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Abstract Three alkaloids named in the title were isolated from the Peruvian plant “Quillo-bordon.” The structures assigned were confirmed by partial syntheses.
G. Büchi, Dana W. Mayo, F.A. Hochstein
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Ellipticine-induced alteration of model and natural membranes
Biochemical Pharmacology, 1983The modification of certain membrane properties by ellipticine derivatives was examined. The amphiphilic 9-methoxyellipticine was the most efficient in disorganizing membrane structure and in inducing leaks of liposomes, haemolysis of intact human erythrocytes.
F, Terce, J F, Tocanne, G, Laneelle
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Dissolution and Absorption of the Antineoplastic Agent Ellipticine
Journal of Pharmaceutical Sciences, 1978Ellipticine, a poorly water-soluble alkaloid, is active in several experimental tumor systems. Marked solubility increases were produced by polyvinylpyrrolidone of varying molecular weights (10,000--160,000) and were optimal (approximately 13 mg/ml at 25 degrees) with polyvinylpyrrolidone mol. wt 10,000. Dissolution of ellipticine--polyvinylpyrrlidone (
A, Rahman, J C, Cradock, J P, Davignon
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An approach to novel ellipticine glycosides
Tetrahedron, 1988Abstract Reactions of 6-methylellipticine (3a) with the aim of preparing various functionalized derivatives have been studied. A base-(LDA) mediated reaction of 3a with formaldehyde results in a C(11)-hydroxyethyl derivative (3d) , which has been coupled with ribose-, glucose- and galactose derivatives to give, after deprotection ...
Albert Langendoen +2 more
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