Results 11 to 20 of about 3,943 (230)

Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells. [PDF]

Protein Sci, 2023
Abstract Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic agents. In this study, we successfully genetically engineered human H ferritin by incorporating 4 or 6 tryptophan residues per subunit, strategically ...
Incocciati A, Kubeš J, Piacentini R, Cappelletti C, Botta S, Bertuccini L, Šimůnek T, Boffi A, Macone A, Bonamore A.   +9 more
europepmc   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models. [PDF]

Mol Oncol
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Classon J, Stenudd M, Zamboni M, Alkass K, Eriksson CJ, Pedersen L, Schörling A, Thoss A, Bergh A, Wikström P, Adami HO, Sørensen HT, Druid H, Frisén J.   +13 more
europepmc   +2 more sources

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β-Hematin Formation from Areas of Enrichment. [PDF]

ChemMedChem
An enrichment map, developed using principal components analysis (PCA), shows the relative abundance of inhibitors of synthetic hemozoin (β‐hematin) formation in antiplasmodium chemical space. This 2‐dimensional landscape can be mined to unearth new chemotypes for antimalarial drug development.
Thibaud JL, Myburgh DC, Sandlin RD, Fong KY, Garnie LF, Wicht KJ, Kuter D, Wright DW, Egan TJ, de Villiers KA.   +9 more
europepmc   +2 more sources

Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats — A Comparative Study

Sensors, 2014
The requirements for early diagnostics as well as effective treatment of cancer diseases have increased the pressure on development of efficient methods for targeted drug delivery as well as imaging of the treatment success.
Marie Stiborova, Zuzana Manhartova, Petr Hodek, Vojtech Adam, Rene Kizek, Eva Frei   +5 more
doaj   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

Free Radical‐Mediated Photocyclization of Triphenylphosphindole Oxides for Photoactivated and Self‐Reported Lipid Peroxidation

Advanced Science, Volume 10, Issue 35, December 15, 2023., 2023
An efficient free radical‐mediated photocyclization for triphenylphosphindole oxide derivatives to generate tribenzophosphindole oxide derivative is reported. Interestingly, this photo‐conversion can efficiently occur in living cells to activate photodynamic therapy and trigger fluorescence “light up” in lipid droplet area under continuous irradiation.
Jianqing Li, Zeyan Zhuang, Jingjing Guo, Xiaobin Dong, Junyi Gong, Ben Zhong Tang, Zujin Zhao   +6 more
wiley   +1 more source

Anticancer and Immunomodulatory Activities of a Novel Water-Soluble Derivative of Ellipticine

Molecules, 2020
Cancer still remains a major public health concern around the world and the search for new potential antitumor molecules is essential for fighting the disease.
Regiane Costa de Oliveira, Gemilson Soares Pontes, Aleksandr Kostyuk, Gabriel B. Coutinho Camargo, Anamika Dhyani, Tetiana Shvydenko, Kostiantyn Shvydenko, Andriy Grafov   +7 more
doaj   +1 more source

The potential mechanism of Chebulae Fructus in the treatment of hepatocellular carcinoma on the basis of network pharmacology

Annals of Hepatology, 2022
Introduction and objectives: Hepatocellular carcinoma (HCC) ranks third on the list of the leading cause for cancer death globally. The treatment of HCC patients is unsatisfactory.
Jialu Jiang, Zhiping Yang, Guoxin Hou, Xuming Yao, Jin Jiang   +4 more
doaj   +1 more source

Toward transferable interatomic van der Waals interactions without electrons: The role of multipole electrostatics and many-body dispersion [PDF]

, 2014
We estimate polarizabilities of atoms in molecules without electron density, using a Voronoi tesselation approach instead of conventional density partitioning schemes.
Koch W., O. Anatole von Lilienfeld, Okabe A., Parr R. G., Szabo A., Tristan Bereau   +5 more
core   +2 more sources

Use of carbon‐13 NMR to identify known natural products by querying a nuclear magnetic resonance database—An assessment

Magnetic Resonance in Chemistry, Volume 61, Issue 11, Page 582-588, November 2023., 2023
This article presents the results of structure searches carried out starting from 58 carbon‐13 NMR data sets recorded on pure organic natural products selected in the Biological Magnetic Resonance Bank (BMRB). Two structural dereplication methods were employed. They proved to be efficient and can be used together in a complementary way.
Jean‐Marc Nuzillard
wiley   +1 more source