Results 31 to 40 of about 3,943 (230)

Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells

Pharmaceuticals, 2019
Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not ...
Charlotte M. Miller, Elaine C. O’Sullivan, Florence O. McCarthy   +2 more
doaj   +1 more source

Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity [PDF]

, 2014
International audienceIn this article, we report a convenient and efficient method for the synthesis of new simplified derivativesof hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groupsas Michael acceptor ...
Doan, Duy Tien, Hoang, Thi Phuong, Jean, Mickael, Ngo, Quoc Anh, Nguyen Van, Tuyen, The, Chinh Pham, Thi, Tham Pham, Thi, Thu Ha Nguyen, Thi, Thu Ha Vu, Thi, Tuyet Anh Dang, van de Weghe, Pierre   +10 more
core   +3 more sources

AROMATASE INHIBITORY AND CYTOTOXIC ACTIVITIES OF CHEMICAL CONSTITUENTS FROM THE VIETNAMESE MEDICINAL PLANT BAN-CHI-LIEN (SCUTELLARIA BARBATA D. DON)

ASEAN Journal on Science and Technology for Development, 2017
Aromatase inhibitory and cytotoxic activities were determined for apigenin, luteolin and the new diterpene named scutebarbalactone VN, which were obtained by bioassay-guided fractionation and isolation from the methanol extract of the Vietnamese ...
Do Thi Thao, Le Quang Huan, Do Khac Hieu, Nguyen Quyet Chien, Nguyen Van Hung   +4 more
doaj   +1 more source

Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells [PDF]

, 2012
Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling ...
Abreu, Bray, Dai, Daniela Peixoto, Dunn, Eugénia Pinto, Isabel C. F. R. Ferreira, Luís A. Vale-Silva, M. Helena Vasconcelos, M. Inês Alvelos, Maria-João R. P. Queiroz, Munchhof, Queiroz, Queiroz, Queiroz, Raquel T. Lima, Ricardo C. Calhelha, Rui M. V. Abreu, Yin, Zheng   +19 more
core   +3 more sources

EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs

Sensors, 2009
In the present study, we characterized the kinetic parameters of 7-ethoxy-resorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) in hepatic microsomes from entire and castrated male pigs.
Vladimir Zlabek, Galia Zamaratskaia
doaj   +1 more source

The cytotoxic activity of lignans and monoterpenoids from the male carica papaya flowers on A549 lung cancer, Hep3B liver cancer, and MCF-7 breast cancer cell lines

Tạp chí Khoa học và Công nghệ, 2023
Two lignans (lariciresinol (1) and dehydrodiconiferyl alcohol (2)), and four monoterpenoids (vitexoid (3), 6-hydroxy-2,6-dimethyl-2,7-octadienoic acid (4), 6-hydroxy-2,6-dimethyloct-7-enoic acid (5), 2,6-dimethylocta-2,7-diene-1,6-diol (6)) from the male
Do Thi Thuy Van
doaj   +1 more source

Alcaloides indólicos de cascas de Aspidosperma vargasii e A. desmanthum Indole alkaloids from the bark of Aspidosperma vargasii and A. desmanthum

Química Nova, 2010
Fractionation of extracts resulted in isolation and identification of indole alkaloids ellipticine and N-methyltetrahydroellipticine from A. vargasii and aspidocarpine from A. desmanthum. Identification of these compounds was achieved based on IR, MS, ¹H,
Marycleuma Campos Henrique, Sergio Massayoshi Nunomura, Adrian Martin Pohlit   +2 more
doaj   +1 more source

Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as Potential Cytotoxic Agents against Human Neuroblastoma

Pharmaceuticals, 2021
We report herein the evaluation of various pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents. These molecules were obtained by developing the multicomponent Groebke–Blackburn–Bienaymé reaction to yield various pyrido[2′,1′:
Zahira Tber, Mohammed Loubidi, Jabrane Jouha, Ismail Hdoufane, Mümin Alper Erdogan, Luciano Saso, Güliz Armagan, Sabine Berteina-Raboin   +7 more
doaj   +1 more source

Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2 [PDF]

, 2008
Porcine cytochrome P450 (CYP) 1A2 was purified to electrophoretic homogeneity from the hepatic microsomes of -naphthoflavone-treated male pigs. In a reconstituted system, this enzyme showed a good catalytic activity towards caffeine, acetanilide, and ...
Chirulli, Vera, Gervasi, Pier Giovanni, Longo, Vincenzo, Messina, Andrea   +3 more
core   +1 more source

Molecules against Covid-19: An in silico approach for drug development

Journal of Electronic Science and Technology, 2021
A large number of deaths have been caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide, turning it into a serious and momentous threat to public health.
Rhythm Bharti, Sandeep Kumar Shukla
doaj   +1 more source