Results 61 to 70 of about 3,943 (230)
Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves) [PDF]
, 2016 The chemical composition and bioactive properties of two plants (Calendula officinalis L. and Mentha cervina L.) were studied. Their nutritional value revealed a high content of carbohydrates and low fat levels, and very similar energy values.
Barros, Lillian +7 more
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Frontiers in Microbiology, 2015 Candida species have emerged as important and common opportunistic human pathogens, particularly in immunocompromised individuals. The current antifungal therapies either have toxic side effects or are insufficiently effect.
Takao eWatamoto +3 more
doaj +1 more source
A smart viral vector for targeted delivery of hydrophobic drugs
Scientific Reports, 2021 Targeted delivery of hydrophobic chemotherapeutic drugs to tumor cells remains a fundamental problem in cancer therapy. Effective encapsulation of hydrophobic drugs in nano-vehicles can improve their pharmacokinetics, bioavailability and prevent off ...
Sukanya Ghosh, Manidipa Banerjee
doaj +1 more source
Molecules, 2022 Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current ...
Kishor Mazumder +9 more
doaj +1 more source
Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity [PDF]
, 2014 Mushrooms are widely appreciated for their organoleptic qualities, being also recognized as good sources of bioactive compounds that provide antioxidant, antimicrobial and cytotoxic activities. Polysaccharides (including glucans) are often pointed out as
Barreira, João C.M. +7 more
core +1 more source
Archiv der Pharmazie, Volume 358, Issue 7, July 2025.A mini‐library of cyclic triimidazo triazine derivatives functionalized with one, two, or three ethynyl‐N‐methyl‐pyridinium moieties was synthesized, characterized for the interaction with cancer‐related G‐quadruplexes, and tested in antiproliferative activity screenings on human cancer cells.
Chiara Platella +10 more
wiley +1 more source
Promising Anti-Mitochondrial Agents for Overcoming Acquired Drug Resistance in Multiple Myeloma
Cells, 2021 Multiple myeloma (MM) remains an incurable tumor due to the high rate of relapse that still occurs. Acquired drug resistance represents the most challenging obstacle to the extension of survival and several studies have been conducted to understand the ...
Vanessa Innao +4 more
doaj +1 more source
Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster [PDF]
, 2017 Four inhibitors of eukaryotic topoisomerases were investigated for genotoxic effects in the wing spot test of Drosophila melanogaster. As a somatic mutation and recombination test (SMART) this assay assesses mitotic recombination and mutational events of
Frei, Hansjörg, Würgler, Friedrich E.
core
Molecular Oncology, Volume 19, Issue 6, Page 1855-1875, June 2025.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Marine Drugs, 2015 This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield.
Sebastien Boucle +3 more
doaj +1 more source