Results 71 to 80 of about 3,943 (230)

Antitumor Activity of New Olivacine Derivatives

Molecules, 2020
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic and
Janusz Piasny, Benita Wiatrak, Agnieszka Dobosz, Beata Tylińska, Tomasz Gębarowski   +4 more
doaj   +1 more source

Extending the Applicability of In Ovo and Ex Ovo Chicken Chorioallantoic Membrane Assays to Study Cytostatic Activity in Neuroblastoma Cells

Frontiers in Oncology, 2021
PurposeThe chick chorioallantoic membrane (CAM) assay can provide an alternative versatile, cost-effective, and ethically less controversial in vivo model for reliable screening of drugs.
Miguel Angel Merlos Rodrigo, Miguel Angel Merlos Rodrigo, Berta Casar, Berta Casar, Hana Michalkova, Hana Michalkova, Ana Maria Jimenez Jimenez, Ana Maria Jimenez Jimenez, Zbynek Heger, Zbynek Heger, Vojtech Adam, Vojtech Adam   +11 more
doaj   +1 more source

Nutritional and biochemical profiling of Leucopaxillus candidus (Bres.) singer wild mushroom [PDF]

, 2016
The wild mushroom Leucopaxillus candidus (Bres.) Singer was studied for the first time to obtain information about its chemical composition, nutritional value and bioactivity.
Barros, Lillian, Ferreira, Isabel C.F.R., Martins, Anabela, Vieira, Vanessa   +3 more
core   +2 more sources

Bis(azo‐mine) Based Transition Metal Complexes: Synthesis, Spectroscopy, DNA Binding, Docking Studies, and α‐Glucosidase Inhibition Activity

Applied Organometallic Chemistry, Volume 39, Issue 6, June 2025.
Two novel mononuclear Zn(II) (2a) and Mn(II) (2b) complexes and a hetero‐binuclear Zn(II)–Cu(II) (3a) complex have been reported. Their biological properties were examined and their computational studies were performed. Particularly, complexes 2b and 3 were observed to have strong interactions with DNA and showed effective antimicrobial ...
Ali Zengin, Kerim Serbest, Nagihan Saglam Ertunga, Melike Yildirim Akatin, Tugba Taskin‐Tok, Abdulmalek Hasan Mohammed Ghaleb, Nebahat Ejder   +6 more
wiley   +1 more source

Pharmacokinetics of peptide mediated delivery of anticancer drug ellipticine.

PLoS ONE, 2012
The amino acid pairing peptide EAK16-II (EAK) has shown the ability to stabilize the hydrophobic anticancer agent ellipticine (EPT) in aqueous solution. In this study, we investigate pharmacokinetics of the formulation of EAK-EPT complexes in vivo.
Weina Ma, Sheng Lu, Pei Pan, Parisa Sadatmousavi, Yongfang Yuan, P Chen   +5 more
doaj   +1 more source

Biological and Chemical Characterization of Musa paradisiaca Leachate

Biology, 2023
There is a growing demand for molecules of natural origin for biocontrol and biostimulation, given the current trend away from synthetic chemical products.
Isabelle Boulogne, Philippe Petit, Lucienne Desfontaines, Gaëlle Durambur, Catherine Deborde, Cathleen Mirande-Ney, Quentin Arnaudin, Carole Plasson, Julie Grivotte, Christophe Chamot, Sophie Bernard, Gladys Loranger-Merciris   +11 more
doaj   +1 more source

Non-edible parts of Solanum stramoniifolium Jacq. - a new potent source of bioactive extracts rich in phenolic compounds for functional foods [PDF]

, 2017
Extracts prepared from leaves, roots, and stems of Solanum stramoniifolium Jacq. (Solanaceae) in 80% ethanol have been tested for their in vitro antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities with an aim to find new sources of ...
Alves, Maria Jose, Barros, Lillian, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Heleno, Sandrina, Kubáň, Vlastimil, Svobodová, Blanka, Walcott, Simone, Šopík, Tomáš   +8 more
core   +2 more sources

An Expedient Flow Chemistry Approach to Substituted 1,4‐Dimethylcarbazoles

ChemistrySelect, Volume 10, Issue 13, April 4, 2025.
The synthesis of substituted carbazoles, a privileged scaffolds in medicinal chemistry was translated to a robust flow chemistry methodology that enables continuous production of target materials. The reaction requires the use of simple indoles and 2,5‐hexanedione catalyzed under flow chemistry conditions through an in‐house constructed Omnifit ...
Jennifer R Baker, Michael Hamilton, Cecilia C. Russell, Nicholas S O'Brien, Fiona M. Deane, Louis E Matheson, Adam McCluskey   +6 more
wiley   +1 more source

Harnessing nanotechnology: ellipticine nanoformulations in the fight against cancer

Cancer Nanotechnology
Ellipticine is a naturally occurring alkaloid that is derived from the plants of Apocynaceae family and has gained a lot of attention for its promising anticancer properties.
Ipshita Das, Vibha Kamath, Krupa Bhat, Yashaswini Reddy, Babitha Kampa Sundara   +4 more
doaj   +1 more source

Horseradish and soybean peroxidases: comparable tools for alternative niches? [PDF]

, 2006
Horseradish and soybean peroxidases (HRP and SBP, respectively) are useful biotechnological tools. HRP is often termed the classical plant heme peroxidase and although it has been studied for decades, our understanding has deepened since its cloning and ...
Alonso Lomillo, Alpeeva, Azevedo, Azevedo, Azevedo, Barry J. Ryan, Bruns, Bódalo, Campanella, Castilho, Castillo, Chen, Cho, Ciarán Ó’Fágáin, Colas, Dachs, Dai, Dai, dos Santos, Dotsikas, Dunford, Duroux, Ferapontova, Ferapontova, Ferapontova, Folkes, Gajhede, Gazaryan, Gazaryan, Gijzen, Gray, Gustafsson, Henriksen, Hoffmann, Howes, Howes, Howes, Hoyle, Hushpulian, Ignatenko, Jung, Kamal, Kamiya, Katz, Kazlauskas, Kenausis, Kim, Kim, Klibanov, Knutson, Konash, Kreiner, Lee, Lei, Li, Li, Lin, Lin, Lindgren, Liu, Luong, Mendive, Michizoe, Morawski, Morawski, Morgan, Morimoto, Mukai, Nagano, Neil Carolan, Newmyer, Newmyer, Nicell, Ozaki, Patel, Paul, Penalva, Poljaková, Rahman, Rauf, Rodriguez-Lopez, Rossiter, Sakharov, Schmitz, Schuvailo, Shipovskov, Smith, Smith, Song, Sun, Tafazoli, Tanaka, Teilum, Tupper, Tønning, van de Velde, van de Velde, Varnado, Veitch, Veitch, Veitch, Veitch, Verpoorte, Vreeke, Wandersman, Wang, Wang, Wanger, Welinder, Welinder, Welinder, Won, Woodard, Wu, Wuhrer, Yan, Yuan, Zhang, Zhang, Zhu   +119 more
core   +2 more sources