Results 141 to 150 of about 298,697 (259)

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Biomarkers of Diabetic Macular Edema on Optical Coherence Tomography After Cataract Surgery. [PDF]

J Vitreoretin Dis
Tran T, Goh J, Rogers S, Qureshi S, Lim LL.   +4 more
europepmc   +1 more source

Rapid Steam‐Assisted Temperature Swing Adsorption for Direct Air Capture Using a Rotary Adsorber

Advanced Science, EarlyView.
This study presents a direct air capture (DAC) device based on a steam‐regeneration rotary adsorber for high‐purity CO2. Testing of the prototype demonstrates its capability for continuous and stable carbon capture with the potential to achieve ton‐scale.
Junye Wu, Yunhao Chen, Kuihua Wang, Yingjie Huo, Yanlin Chen, Quanwen Pan, Tianshu Ge   +6 more
wiley   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Clarifying comparative evidence on epcoritamab. [PDF]

Blood Adv
Danilov AV.
europepmc   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

Robust Incipient Fault Diagnosis of Rolling Element Bearings Under Small-Sample Conditions Using Refined Multiscale Rating Entropy. [PDF]

Entropy (Basel)
Wu S, Liu H, Tao L.
europepmc   +1 more source

Dual‐Band Modulation of Emissivity and Solar Transmittance Through Chemical Composition‐Tuned Asymmetric Layer‐by‐Layer Assembly

Advanced Science, EarlyView.
An unconventional asymmetric Layer‐by‐Layer (LbL) assembly technique was developed to fabricate a Fabry‐Pérot (F‐P) resonator, which enhances luminous transmittance (Tlum) and enables dual‐band modulation in both the near‐infrared (NIR) and mid‐infrared (MIR) regions.
Hebing Hu, Zhengui Zhou, Guanya Wang, Xiaofei Li, Yun Meng, Tao Xu, Xiao'e Jia, Hao Yu, Yuhan Wang, Jiarui Wang, Yi Long   +10 more
wiley   +1 more source

Reassuring cardiac and non-cardiac outcomes for heart failure patients managed in a disease management programme during the COVID-19 pandemic

International Journal of Cardiology: Heart & Vasculature, 2022
Joseph McCambridge, Katherine McDonald, Líbhan Collins, Barry Dyer, Carmel Halley, Matthew Barrett, Mark Ledwidge, Kenneth McDonald   +7 more
doaj   +1 more source