Results 131 to 140 of about 6,842,647 (311)

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Fusion Burn Regulation via Deuterium Tritium Mixture Control in the Joint European Torus

PRX Energy
The first generation of nuclear fusion reactors is expected to operate using a mixture of deuterium (D) and tritium (T) fuel. Controlling the D:T ratio is a promising option to control the fusion burn rate.
M. Lennholm, L. Piron, D. Valcarcel, P. Almond, M. Baruzzo, M. van Berkel, T. Bosman, L. Ceelen, P. Fox, K. Kirov, B. Kool, C. Lowry, J. Mitchell, B. Sieglin, H. Sun   +14 more
doaj   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Finding the Place [PDF]

, 1988
Print Edition: 300 copies.Print Pages: 1 broadsidePrint Illustrations: ill. (reduction woodcut)Printing: LetterpressPaper: Curtis Rag paperTypography: Handset JansonPhysical Dimensions: 59.5 x 23.8 cmColophon: Three hundred copies of this excerpt from ...
Sanders, Scott Russell
core  

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Two poems By Jon Silkin [PDF]

, 1985
Print Edition: 125 copies.Print Pages: 1 sheetPrint Illustrations: ill. (woodcut)Printing: LetterpressBinding: Tri-foldPaper: Rives HeavyweightTypography: Handset CentaurPhysical Dimensions: 25.5 x 11 cmColophon: 125 copies with woodcuts by Sidney ...
Silkin, Jon
core  

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Active tungsten expulsion in ELM-absent H-mode plasmas via on-demand ELM triggering with lithium granule injection

Nuclear Fusion
Lithium granules gravitationally injected into the upper X -point region demonstrated on-demand edge-localized modes (ELM) triggering in otherwise ELM-suppressed H-mode plasmas on the Experimental Advanced Superconducting Tokamak. Sub-mm lithium granules
Z. Sun, R. Maingi, Y.X. Cheng, Y.Z. Qian, W. Xu, Z. Wang, L. Zhang, A. Bortolon, Y.M. Duan, M. Huang, Y.F. Wang, J. Huang, T. Zhang, L. Chen, W. Wang, J.H. Yang, Y.Y. Li, D.G. Wu, K. Jia, H.L. Zhao, Q. Zhang, K. Tritz, H.Q. Wang, R. Lunsford, A. Nagy, A. Diallo, G.Z. Zuo, X.Z. Gong, J.S. Hu, the EAST Team   +29 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source