Results 171 to 180 of about 22,670 (283)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Superimposed CSI Feedback Assisted by Inactive Sensing Information. [PDF]

open access: yesSensors (Basel)
Zhang M   +6 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

open access: yesThe FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak   +10 more
wiley   +1 more source

Development of CCMb: A Low‐Mg Calcite Reference Material for In Situ Measurement of δ18O, δ13C and Selected Trace Elements

open access: yesGeostandards and Geoanalytical Research, EarlyView.
Key Points Low‐Mg calcite RM developed for in situ microanalysis applications in palaeoclimatology (δ18O, δ13C; Mg, Sr m/m). New data for calcite CRM IAEA‐603 (δ18O, δ13C by SIMS and GS‐IRMS; Mg m/m). No detectable IMF effect of Mg on SIMS δ18O determinations for mass fractions < 3650 μg g‐1.
Andreas T. Hertwig   +13 more
wiley   +1 more source

Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan. [PDF]

open access: yesAm J Physiol Heart Circ Physiol
Wang M   +12 more
europepmc   +1 more source

Contagious Effect of Nurses' Perception of Leaders' Antisocial Behaviour

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine the underlying mechanism that strengthens or attenuates the social contagion effect among nursing professionals. Design The study uses a cross‐sectional design. The study's results followed the Strengthening Reporting of Observational Studies in Epidemiology (STROBE).
Kwadwo Asante   +3 more
wiley   +1 more source

Haematological and histopathological monitoring of monosodium glutamate–supplemented feeding in rainbow trout (Oncorhynchus mykiss): A possible modelling for a single health approach

open access: yesJournal of Fish Biology, EarlyView.
Abstract The aim of this study was to investigate the potential effects of monosodium glutamate (MSG), a known flavour enhancer added to many ready‐to‐eat foods, as a feed additive in rainbow trout (Oncorhynchus mykiss). Evaluating the effects of MSG on aquatic organisms will fill the knowledge gap in this field by monitoring the haematological indices
Gonca Alak   +16 more
wiley   +1 more source

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