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Biocompatible ELR-Based Polyplexes Coated With MUC1 Specific Aptamers and Targeted for Breast Cancer Gene Therapy [PDF]

open access: yesMolecular Pharmaceutics, 2016
The search for new and biocompatible materials with high potential for improvement is a challenge in gene delivery applications. A cell type specific vector made of elastin-like recombinamer (ELR) and aptamers has been specifically designed for the ...
José Carlos Rodriguez-Cabello   +2 more
exaly   +2 more sources
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Functional Characterization of the ELR Motif in Piscine ELR+CXC-Like Chemokine

Marine Biotechnology, 2008
To elucidate the functional role of piscine incomplete ELR motif, the recombinant CXC and its mutants (mELR and mLoop) were produced in Escherichia coli M15 based on the predicted mature peptide coding sequence of the black sea bream CXC (BS CXC) chemokine.
Zhonghua, Cai   +3 more
openaire   +2 more sources

The Ratio of ELR+ to ELR− CXC Chemokines Affects the Lung and Liver Injury Following Hepatic Ischemia/Reperfusion in the Rat

Hepatology, 2000
Hepatic ischemia/reperfusion (I/R) results in a neutrophil-dependent lung and liver injury. The process of neutrophil recruitment and activation in this injury is at least partially dependent on the presence of the ELR+ CXC chemokines.
Robert M. Strieter   +2 more
exaly   +3 more sources

ELR+ CXC chemokines in human milk

Cytokine, 2003
CXC chemokines bearing the glutamic acid-leucine-arginine (ELR) motif are crucial mediators in neutrophil-dependent acute inflammation. Interestingly, however, Interleukin (IL)-8/CXC ligand (CXCL) 8 is expressed in human milk in biologically significant concentrations, and may play a local maturational role in the developing human intestine.
Akhil, Maheshwari   +2 more
openaire   +2 more sources

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