Results 91 to 100 of about 5,420 (200)

In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota

Frontiers in Cellular and Infection Microbiology
IntroductionAntiretroviral therapy has improved life expectancy in HIV-infected patients. However, people living with HIV under antiretroviral therapy are at higher risks of developing chronic complications and acquiring multidrug resistant bacteria than
Elisa Rubio-Garcia, Elisa Rubio-Garcia, Elisa Rubio-Garcia, Elisa Rubio-Garcia, Núria Ferrando, Núria Martin, Clara Ballesté-Delpierre, Clara Ballesté-Delpierre, Jose M. Miró, Jose M. Miró, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Climent Casals-Pascual, Climent Casals-Pascual, Climent Casals-Pascual, Climent Casals-Pascual, Jordi Vila, Jordi Vila, Jordi Vila, Jordi Vila   +21 more
doaj   +1 more source

Safety of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-1-infected adults with end-stage renal disease on chronic haemodialysis: an open-label, single-arm, multicentre, phase 3b trial.

The Lancet HIV, 2019
BACKGROUND Current treatment for HIV-infected individuals with renal failure on haemodialysis frequently requires complex regimens with multiple pills. A daily single-tablet regimen of coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir ...
J. Eron, J. Lelièvre, R. Kalayjian, J. Slim, A. Wurapa, J. L. Stephens, Cheryl Mcdonald, E. Cua, Aimee Wilkin, B. Schmied, M. McKellar, S. Cox, Sophia R Majeed, Shuping Jiang, A. Cheng, M. Das, Devi SenGupta   +16 more
semanticscholar   +1 more source

Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection

Therapeutics and Clinical Risk Management, 2009
Christine Katlama, Robert MurphyPierre et Marie Curie Université – Paris 6, Service de Maladies Infectieuses et Tropicales, Paris, FranceAbstract: Integrase is an essential HIV-1-specific enzyme that is an active target for ...
Christine Katlama, Robert Murphy
doaj  

Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors.

PLoS ONE, 2013
Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses).
Jan Weber, Justine D Rose, Ana C Vazquez, Dane Winner, Nicolas Margot, Damian J McColl, Michael D Miller, Miguel E Quiñones-Mateu   +7 more
doaj   +1 more source

Integrase inhibitor drugs during pregnancy and congenital anomalies: A case/non‐case study from the global pharmacovigilance database VigiBase®

Pharmacology Research & Perspectives
In 2018, a significant neural tube defects (NTD) signal was reported after pre‐conceptional exposure to dolutegravir, but was not confirmed in further analysis.
Laura Saint‐Lary, Isabelle Lacroix, Valériane Leroy, Agnès Sommet   +3 more
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Elvitegravir [PDF]

, 2020
openaire   +1 more source

Efficacy, safety, and patient acceptability of elvitegravir/cobicistat/emtricitabine/tenofovir in the treatment of HIV/AIDS

Patient Preference and Adherence, 2015
Roberta Prinapori,1 Antonio Di Biagio2 1Infectious Diseases, University of Genoa, Genoa, Italy; 2Unit of Infectious Diseases, IRCCS AOU San Martino-IST, Genoa, Italy Abstract: The fixed-dose combination (FDC) elvitegravir/cobicistat/emtricitabine ...
Prinapori R, Di Biagio A
doaj  

Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV

Drug Design, Development and Therapy, 2015
Christopher E Kandel,1 Sharon L Walmsley1,21Department of Medicine, University of Toronto, Toronto, ON, Canada; 2Division of Infectious Diseases, University Health Network, Toronto, ON, CanadaAbstract: Dolutegravir is the newest integrase strand transfer
Kandel CE, Walmsley SL
doaj  

A robust pH-based second-order spectrophotometric method for the analysis of four anti-HIV drugs in pharmaceutical formulations

Scientific Reports
A robust pH-based second-order spectrophotometric strategy combined with parallel factor analysis (PARAFAC) was developed for the simultaneous determination of elvitegravir (EVG), cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (
S. Noroozi Eshlaqi, M. R. Khoshayand, N. Dalali, S. Vali Zade, H. Abdollahi   +4 more
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Hyperlipidemia and associated risk factors among people living with HIV on antiretroviral therapy: a retrospective cohort study from Eastern China. [PDF]

Prev Med Rep
Cheng W, Zhang Y, Yang J, Jiang J, Pan X, Chai C, Wang Y.   +6 more
europepmc   +1 more source