Results 21 to 30 of about 5,420 (200)

Safety and efficacy of switching to elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate in treatment-experienced people with HIV: a multicenter cohort study

AIDS Research and Therapy, 2023
Objectives We assessed the virologic efficacy of switching to co-formulated elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate (E/C/F/TDF) in patients with controlled HIV infection.
N. De Castro, A. Brun, P. Sellier, Gwenn Hamet, F. Mechaï, V. Garrait, A. Chabrol, M. Bouldouyre, E. Froguel, D. Troisvallets, P. Caraux-Paz, C. Delaugerre, W. Rozenbaum, J. Molina   +13 more
semanticscholar   +1 more source

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

Viruses, 2015
Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of ...
Thibault Mesplède, Mark A. Wainberg
doaj   +1 more source

Pharmacokinetic drug interactions of integrase strand transfer inhibitors

Current Research in Pharmacology and Drug Discovery, 2021
The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection.
Chi-Hua Lu, Edward M. Bednarczyk, Linda M. Catanzaro, Alyssa Shon, Jia-Chen Xu, Qing Ma   +5 more
doaj   +1 more source

Presentations Due to Priapism in an Urban Hospital in Switzerland. [PDF]

Emerg Med Int
Objective Priapism, a persisting erection not associated with sexual stimulation, can be ischaemic, with the risk of permanent erectile dysfunction, or nonischaemic. Drugs—e.g., injection therapies for erectile dysfunction, as well as neuroleptics, antidepressants and various other medicines—can also cause priapism.
Uhl JD, Koneval L, Schneidewind L, Haschke M, Exadaktylos A, Liakoni E.   +5 more
europepmc   +2 more sources

A novel validated RP-UPLC for the simultaneous estimation of Emtricitabine, Tenofovir Disoproxil Fumarate, Cobicistat and Elvitegravir in tablet dosage form

Journal of Population Therapeutics and Clinical Pharmacology, 2023
The present study provides us a single analytical tool for the determination of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate in dosage forms.
Swapna Vemireddy, G. Kumaraswamy
semanticscholar   +1 more source

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Frontiers in Molecular Neuroscience, 2023
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs).
H. Monnerie, Micah A Romer, Lindsay M. Roth, Caela C Long, John S. Millar, K. Jordan-Sciutto, J. Grinspan   +6 more
semanticscholar   +1 more source

Elvitegravir: A New HIV Integrase Inhibitor [PDF]

Antiviral Chemistry and Chemotherapy, 2009
Integration is a distinctive and essential process in the HIV infection cycle and thus represents an attractive antiviral drug target. Integrase inhibitors combined with other classes of drug might contribute to long-lasting suppression of HIV type-1 (HIV-1) replication for many patients.
Kazuya, Shimura, Eiichi N, Kodama
openaire   +2 more sources

Treatment-related early discontinuations and adverse events among newly diagnosed people living with HIV initiating integrase inhibitors in a real-world setting

Antiviral Therapy, 2023
Background Cohort studies suggest higher discontinuation rates with integrase strand transfer inhibitors (INSTIs) than are seen in clinical trials. We assessed discontinuations and adverse events (AEs) that were considered related to the initial INSTI in
Charlotte-Paige Rolle MD, MPH, Jamie Castano, Vu Nguyen MS, Kiran Patel, Federico Hinestrosa MD, Edwin DeJesus MD   +5 more
doaj   +1 more source

Inhibition of HTLV-1 Infection by HIV-1 First- and Second-Generation Integrase Strand Transfer Inhibitors

Frontiers in Microbiology, 2019
More than 10 million people worldwide are infected with the retrovirus human T-cell lymphotropic virus type 1 (HTLV-1). Infection phenotypes can range from asymptomatic to severe adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy ...
Michał S. Barski, Jordan J. Minnell, Goedele N. Maertens   +2 more
doaj   +1 more source

A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

Molecular Brain, 2020
Glutamate toxicity is a pathomechanism that contributes to neuronal cell death in a wide range of acute and chronic neurodegenerative and neuroinflammatory diseases.
Simon F. Merz, C. Peter Bengtson, Clara Tepohl, Anna M. Hagenston, Hilmar Bading, Carlos Bas-Orth   +5 more
doaj   +1 more source