Results 51 to 60 of about 5,964 (280)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Contribution of Emanationist Philosophy to the Development of Environmental Conservation
An-Nida'The global ecological crisis demonstrates that contemporary ethical frameworks have been insufficient in mitigating the accelerating rate of environmental degradation.
Rifqah Najwa Azizah +3 more
doaj +1 more source
No Ontological Leaps: A Primer on Scientific Materialism [PDF]
Integral Review, 2011 When the issue is intelligence in nature, arguments about whether science supports neo-Darwinian theory or intelligent design miss the point. The details of evolution or the structure of the brain are irrelevant because biology and neuroscience have ...
Christian de Quincey
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The theory of 'emanation' in Gikatilla's Gates of Justice
, 2011 In the present article, I analyse the word field of 'emanation' in the treatise Gates of Justice, written by the kabbalist Joseph ben Abraham Gikatilla (1248-c. 1325).
Federico Dal Bo
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Measurement of radon in soils of Lima City - Peru during the period 2016-2017
Earth Sciences Research Journal, 2019 Lima City is situated on alluvial fan deposits of rivers flowing through geological formations that contain different levels of uranium. In this paper, a study is made on the average spatial and temporal behavior of radon gas in soils of Lima City. Radon
Luís Vilcapoma Lázaro +6 more
doaj +1 more source
Symbolic Emanations of God’s Great Title in Monotheism figures in the Islamic Art and Architecture Works [PDF]
نگره, 2017 The main issue is to study the quality of semantic implications of God’s great title in Islamic art and architecture works. The purpose is to gain the secret behind immortality of symbolic language of forms, figures, patterns, and structures of Islamic ...
fatemeh akbari
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source