Results 41 to 50 of about 4,832 (251)

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Short‐term response to biologic therapy in psoriatic arthritis (PsA) is not influenced by disease duration at initiation of therapy

Arthritis Care &Research, Accepted Article.
Objectives We aimed to determine whether the short‐term response to biologics in biologic‐naïve psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods PsA patients who started biologic therapy from the year 2000 to 2025 were included for analysis. Patients considered in the early treatment (ET)
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Survival of trauma patients requiring massive transfusion protocol activation: A retrospective cohort study at a tertiary hospital in Malaysia

Hematology, Transfusion and Cell Therapy
Background: Trauma is one of the main causes of morbidity and mortality worldwide. Understanding the factors affecting the survivability of trauma patients is crucial, especially those requiring the activation of the massive transfusion protocol.
Mohd Redzuan Abdullah, Thaenujah Nair Ramachandran, Aidil Noor Adnan, Azian Md Yacob, Siti Fatimah Mohamed Kamaruzzaman, Ahmad Zakimi Abdullah, Nurul Aiman Addenan, Maryam Sumaiya Ahmad Termizi, Joan Gan Cheau Yan, Seniyah Md Sikin, Low Wen Ying, Azarina Zakaria, Wagner Loo Cheng Poh, Zulkifli Hassan, Alex Lim Tat Leong, Siti Aisah Hassan   +15 more
doaj   +1 more source

Non‐Monotonic Changes in the Thermal Conductivity of Conjugated Polymer Films with Increasing Levels of Chemical Doping

Advanced Functional Materials, EarlyView.
Thermal conductivity changes non‐monotonically as regioregular (RR) and regiorandom (RRa) P3HT films are doped with F4TCNQ as a function of the extent to which P3HT is doped: an increase in thermal conductivity is observed upon lightly doping P3HT compared to the undoped film, followed by a decrease in the heavily doped regime. ABSTRACT The performance
Reid W. Wilson, Xinping Shi, Diego Garcia Vidales, Abigail Slimp, Zerina Mehmedović, Alexander F. Simafranca, Eric C. Wu, Sarah H. Tolbert, Richard B. Wilson, Benjamin J. Schwartz   +9 more
wiley   +1 more source

Programmable 2D Magnetic Clusterphenes With High Curie Temperature and Strong Magnetic Anisotropy via Cluster Assembly and Ligand Synergy

Advanced Functional Materials, EarlyView.
Programmable 2D magnetic clusterphenes are realized through a ligand‐mediated cluster‐assembly strategy. Direct linking of magnetic superatomic clusters enhances electron delocalization and symmetry breaking, enabling the concurrent strengthening of magnetic exchange interactions and spin–orbit coupling.
Junxiang Fu, Zhuohang Fang, Haidi Wang, Ye Yang, Weiduo Zhu, Weiwei Chen, Yu Zhang, Haixiao Xiao, Zhao Chen, Hongyan Lv, Xiaofeng Liu, Xiangyang Li, Xiao Cheng Zeng, Zhongjun Li   +13 more
wiley   +1 more source

Surface Properties of Nanostructured Gold Coatings Electrodeposited at Different Potentials

International Journal of Electrochemical Science, 2020
Nanostructured gold coating were synthesized on the surface of screen-printed carbon electrode (SPCE) via electrodeposition technique from acidic gold solution at four different potentials (i.e.: +1.0 V, +0.48 V, -0.3 V and -0.7 V).
Mohammad Hafizudden Mohd Zaki, Yusairie Mohd, Lim Ying Chin   +2 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

The number of androgen receptor CAG repeats and mortality in men

The Aging Male, 2022
Introduction The androgen receptor (AR) mediates peripheral effects of testosterone. Evidence suggests that the number of CAG repeats in exon-1 of the AR gene negatively correlates with AR transcriptional activity.
Adrian Heald, Michael Cook, Leen Antonio, Dirk Vanderschueren, Ahmed Javed, Helene Fachim, Geoff Hackett, Fred Wu, Terence O’Neill   +8 more
doaj   +1 more source