Results 31 to 40 of about 192,922 (261)
ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen +5 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Language Agnostic Code Embeddings
Recently, code language models have achieved notable advancements in addressing a diverse array of essential code comprehension and generation tasks. Yet, the field lacks a comprehensive deep dive and understanding of the code embeddings of multilingual code models.
Saiteja Utpala, Alex Gu, Pin-Yu Chen
openaire +2 more sources
Image coding with face descriptors embedding
Content descriptors, useful for browsing and retrieval tasks, are generally extracted and treated as a separate entity with respect to the nature of the content itself. At the same time, conventional coding processes do not take into account information carried out by content descriptors.
BOSCHETTI, Alberto +3 more
openaire +1 more source
Diversity Embedded Codes: Theory and Practice [PDF]
Diversity embedded codes are high-rate space-time codes that have a high-diversity code embedded within them. They allow a form of communication where the high-rate code opportunistically takes advantage of good channel realizations while the embedded high-diversity code provides guarantees that at least part of the information is received reliably ...
Dusad, Sanket +3 more
openaire +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Fast algorithm and architecture for embedded block coding
To solve the problem of inefficiency of implementing embedded block coding in JPEG 2000, a novel fast algo- rithm to achieve word-level sequential and parallel bit plane coding (BPC) was proposed.
XIONG Cheng-yi1 +3 more
doaj +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source

