Results 51 to 60 of about 918,238 (314)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
IEEE Access, 2019 Combined with the Internet of Vehicles, some intelligent systems for connected health can make medical vehicles transport medical supplies more safely and timely in response to catastrophic natural disasters or serious accidents.
Jiujun Cheng +6 more
doaj +1 more source
Embeddings of Resolvable Triple Systems
Journal of Combinatorial Theory, Series A, 2000 A resolvable triple system of order \(v\) can appear as a subsystem of a resolvable triple system of order \(u\) when \(u=v\) or \(u\geq 3v\), and \(u\) and \(v\) are both multiples of \(3\). When the index is odd, \(u\) and \(v\) must also be odd; and when the index is singly even, \(v\) cannot be \(6\) as no resolvable triple system of order \(6 ...
Yizhu Wang, Hao Shen
openaire +3 more sources
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Traffic Flow Data Prediction Using Residual Deconvolution Based Deep Generative Network
IEEE Access, 2019 Traffic flow prediction is quite crucial for estimating the future traffic states, efficient and accurate prediction models greatly contribute to the smooth traffic of road networks.
Di Zang +4 more
doaj +1 more source
Scientific Reports, 2023 Recently, the Microservices whole link whole life cycle optimization framework has been a research hotspot in the academic and engineering fields, especially how to encapsulate the component security mechanism and conduct high concurrency testing based ...
Shuo Sheng
doaj +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Embeddings of Steiner triple systems
Discrete Mathematics, 1973 SCOPUS: ar.j ; info:eu-repo/semantics ...
Doyen, Jean, Wilson, Richard R.M.
openaire +2 more sources
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source