Results 51 to 60 of about 92,904 (292)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Spectral Nonlinearly Embedded Clustering Algorithm [PDF]
Mathematical Problems in Engineering, 2016 As is well known, traditional spectral clustering (SC) methods are developed based on themanifold assumption, namely, that two nearby data points in the high-density region of a low-dimensional data manifold have the same cluster label. But, for some high-dimensional and sparse data, such an assumption might be invalid.
Liu, Mingming +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Research of embedding algorithm for wireless network virtualization
Tongxin xuebao, 2017 Wireless network virtualization has become one of the promising techniques in fifth generation mobile networks (5G),and the virtual network embedding plays a very important role.A model was formulated to describe the problem and a wireless virtual ...
Bin CAO, Shi-chao XIA, Fang HE, Yun LI
doaj
Hilbert-Curve Assisted Structure Embedding Method
, 2020 This work introduces a novel chemical space embedding method "Hilbert-Curve Assisted Structure Embedding (HCASE)" with help of pseudo-Hilbert Curves and Scaffold- Keys.
Kanny K., Wan +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Applied Network Science, 2020 This paper introduces the strain elevation tension spring embedding (SETSe) algorithm. SETSe is a novel graph embedding method that uses a physical model to project feature-rich networks onto a manifold with semi-Euclidean properties.
Jonathan Bourne
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source