Results 81 to 90 of about 6,473,960 (319)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Deep Metric Learning via Lifted Structured Feature Embedding

, 2015
Learning the distance metric between pairs of examples is of great importance for learning and visual recognition. With the remarkable success from the state of the art convolutional neural networks, recent works have shown promising results on ...
Jegelka, Stefanie, Savarese, Silvio, Song, Hyun Oh, Xiang, Yu   +3 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Some Results On Convex Greedy Embedding Conjecture for 3-Connected Planar Graphs

, 2009
A greedy embedding of a graph $G = (V,E)$ into a metric space $(X,d)$ is a function $x : V(G) \to X$ such that in the embedding for every pair of non-adjacent vertices $x(s), x(t)$ there exists another vertex $x(u)$ adjacent to $x(s)$ which is closer to $
A. Kelmans, A. Kelmans, A. Rao, A.E.F. Clementi, C. Monma, C. Thomassen, C.H. Papadimitriou, F. Kuhn, J.A. Bondy, P. Angelini, P. Bose, P. Bose, T. Leighton, W.T. Tutte   +13 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Constant approximation algorithms for embedding graph metrics into trees and outerplanar graphs

, 2010
In this paper, we present a simple factor 6 algorithm for approximating the optimal multiplicative distortion of embedding a graph metric into a tree metric (thus improving and simplifying the factor 100 and 27 algorithms of B\v{a}doiu, Indyk, and ...
Chepoi, Victor, Dragan, Feodor, Newman, Ilan, Rabinovich, Yuri, Vaxes, Yann   +4 more
core   +3 more sources

Group Embeddings with Algorithmic Properties [PDF]

Communications in Algebra, 2015
We show that every countable group H with solvable word problem (=computable group) can be subnormally embedded into a 2-generated group G which also has solvable word problem. Moreover, the membership problem for H < G is also solvable. We also give estimates of time and space complexity of the word problem in G and of the membership problem for H &
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Efficient Algorithms for Embedded Tactile Data Processing

, 2022
This chapter presents a survey of the existing algorithms and tasks applied for tactile data processing. The presented algorithms and tasks include machine learning, deep learning, feature extraction, and dimensionality reduction. Moreover, this chapter provides guidelines for selecting appropriate hardware platforms for the algorithm’s implementation.
Younes H., Alameh M., Ibrahim A., Rizk M., Valle M.   +4 more
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source