Results 41 to 50 of about 1,711,365 (283)

Embedment behaviour of fully threaded bolts in glued laminated timber

open access: yes, 2023
International audienceAs one of the main factors governing the load-carrying capacity of timber connections with dowel-type fasteners, embedment strength is a system property, which is dependent not only upon the material properties but also upon the ...
Xu, Bo-Han   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Key Parameters to Strength of an Adhesive Anchoring Systemin Uncracked and Cracked Concrete [PDF]

open access: yesWarasan Witthayasat Lae Theknoloyi Mahawitthayalai Mahasarakham, 2019
This study developed a 3D finite element model of an adhesive anchoring system to study key parameters including bond strength of adhesive, embedment depth and concrete strength, that affecting pull-out strength in uncracked and cracked concrete.
Griengsak Kaewkulchai
doaj  

Embedding Strength of Wood Exposed to Decay Fungi

open access: yesMokuzai Gakkaishi, 2007
ASTM-D5764に準拠した面圧試験を,オオウズラタケによる強制腐朽操作を施したスギ,カラマツ,ベイマツ,スプルースの心材およびスギ辺材,ならびに含水率の異なるスギ,カラマツ,ベイマツ,スプルースの健全材に対して実施した。健全材の面圧強度は,樹種や加力方向によらず,繊維飽和点(含水率28%)以下では含水率の増加とともに直線的に低下し,繊維飽和点以上ではほぼ一定となった。その値は気乾状態の約50%であった。腐朽による強度低減はスプルース心材,スギ辺材で顕著であった。他の樹種では繊維平行方向加力では強度低減は発生しなかったが,直交方向加力ではカラマツ心材,ベイマツ心材でも強度低減が発生,腐朽10週目までに強度低減が生じていないのはスギ心材のみであった ...
Hiroshi Takiuchi   +5 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Experimental evaluation of the cyclic behavior of implanted reinforced concrete shear walls

open access: yesFracture and Structural Integrity
Adding new reinforced concrete (RC) shear walls is a widely adopted strategy for seismic strengthening of deficient RC buildings; however, the global performance of such walls depends critically on the reliability of the wall–foundation connection.
Suzan Mustafa   +3 more
doaj   +1 more source

Influence of Pre-Stressing on Tieback Retaining Wall for Sandy Soils Excavations

open access: yesJournal of the Civil Engineering Forum, 2021
Pre-stressed ground anchor systems or tieback systems are commonly used at wide and irregular-shaped excavations, with the advantage of lower cost and ease of construction compared to the braced excavations, but they come with the drawback on permits for
Anthonius Steven Sutanto   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

An experimental study of axial load transfer mechanisms of cable bolts using axially split embedment apparatus

open access: yes, 2017
The load transfer mechanisms of cable bolts differ from those for normal rebar bolts. The cable bolts used in mines are basically steel strands with different constructions depending on the number of wires or elements and the way they are laid.
N Aziz   +3 more
core   +1 more source

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