Results 81 to 90 of about 70,425 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Avoided emissions of a fuel-efficient biomass cookstove dwarf embodied emissions

Development Engineering, 2016
AbstractThree billion people cook their food on biomass-fueled fires. This practice contributes to the anthropogenic radiative forcing. Fuel-efficient biomass cookstoves have the potential to reduce CO2-equivalent emissions from cooking, however, cookstoves made from modern materials and distributed through energy-intensive supply chains have higher ...
Wilson, D. L., Talancon, D. R., Winslow, R. L., Linares, X., Gadgil, A. J.   +4 more
openaire   +2 more sources

Allocating the Burdens of Climate Action: Consumption-Based Carbon Accounting and the Polluter-Pays Principle [PDF]

, 2018
Action must be taken to combat climate change. Yet, how the costs of climate action should be allocated among states remains a question. One popular answer—the polluter-pays principle (PPP)—stipulates that those responsible for causing the problem should
A Agarwal, A Gosseries, A Kander, C Armstrong, CM Duarte, D Bell, D Jamieson, D Jamieson, D Moellendorf, D Moellendorf, Dieter Lüthi, E Kingston, E Neumayer, EA Page, EA Page, G Peters, G Peters, G. P. Peters, Gail Whiteman, H Shue, H Shue, K Steininger, K Steininger, M Lenzen, M Rendall, M Weitzman, MA Delucchi, P Baer, P Baer, R Eckersley, R Schüssler, Rachel James, S Barrett, S Caney, S Caney, S Caney, S Caney, S Caney, Saleemul Huq, SJ Davis, SM Gardiner, SM Gardiner, Susanne Droege, T Athanasiou, T Brooks, WD Nordhaus   +45 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

GHGs and air pollutants embodied in China's international trade: Temporal and spatial index decomposition analysis.

PLoS ONE, 2017
Temporal index decomposition analysis and spatial index decomposition analysis were applied to understand the driving forces of the emissions embodied in China's exports and net exports during 2002-2011, respectively.
Zhengyan Liu, Xianqiang Mao, Peng Song
doaj   +1 more source

Carbon emissions embodied in international trade: The post-China era

Applied Energy, 2016
Abstract The so-called post-China countries (PC-16s), distinguished by low wages and high economic growth, will replace China as the “world’s factory”. The aim of this paper is to assess the effect of these changes on global CO 2 emissions pathways.
Arce, Guadalupe, López, Luis Antonio, Guan, Dabo   +2 more
openaire   +4 more sources

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

Energy-Dominated Local Carbon Emissions in Beijing 2007: Inventory and Input-Output Analysis

The Scientific World Journal, 2012
For greenhouse gas (GHG) emissions by Beijing economy 2007, a concrete emission inventory covering carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) is presented and associated with an input-output analysis to reveal the local GHG embodiment ...
Shan Guo, J. B. Liu, Ling Shao, J. S. Li, Y. R. An   +4 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source